Epidermal growth factor and fibroblast growth factor-2 circulating levels in elderly with major depressive disorder

Hanjing Emily Wu, Antonio L. Teixeira, Lucelia Barroso, Ana Paula Mendes Silva, Mariana de Souza Nicolau, Jéssica Diniz Rodrigues Ferreira, Laiss Bertola, Erica Marciano Vieira, Breno Satler Diniz

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Epidermal growth factor (EGF) and Fibroblast Growth Factor-2 (FGF-2) are growth factors involved neuronal growth and synaptic plasticity. These markers have been implicated in neuropsychiatric disorders, including major depression. However, no particular studies of EGF and FGF-2 have been conducted in older adults with major depressive disorder (MDD). In this study, we aim to investigate the plasma levels of EGF and FGF-2 in elderly with MDD. We included 89 older adults with MDD and 51 older (healthy control, HC) adults. The cognitive performance was evaluated by the Mattis Dementia Rating Scale (MDRS). The EGF and FGF-2 were measured by using multiplex assay for LUMINEX platform. There were also no significant differences between the patient group in terms of plasma levels of EGF and FGF-2 when compared to the HC group. There were not any significant correlations between plasma levels of EGF or FGF2 and MDRS total or individual scores in patient group and HC. There were significant correlations between plasma levels of EGF and FGF2 in both patient group and HC. Further study on plasma levels of EGF and FGF2 should be implemented in larger samples in elderly with MDD.

Original languageEnglish (US)
Pages (from-to)141-143
Number of pages3
JournalPsychiatry Research
Volume272
DOIs
StatePublished - Feb 2019
Externally publishedYes

Keywords

  • Angiogenesis
  • Cognitive performance
  • Late-life depression (LLD)
  • Mattis Dementia Rating Scale (MDRS)
  • Neuronal growth
  • Neuropsychiatric
  • Synaptic plasticity

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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