Epidemiologic typing of Streptococcus pneumoniae invasive isolates from South Texas

Jan E Patterson, E. K. Eskew, D. M. Hicks, J. Elliott, M. Cetron, A. Schuchat, J. H. Jorgensen

Research output: Contribution to journalArticle

Abstract

Drug-resistant S. pneumoniae (DRSP) continue to emerge and the epidemiologic typing of DRSP is important in determining mechanisms of spread. Population-based surveillance for invasive DRSP isolates was conducted in the San Antonio area during 1994-96. Susceptibility testing was performed on all isolates. 52 of 522 (10%) invasive pneumococcal isolates were resistant to penicillin (MIC >2 μg/ml) (PRSP). Serotyping and pulsed-field gel electrophoresis (PFGE) typing was performed on PRSP isolates. Per cent resistant of the 52 PRSP to other antibiotics were as follows: cefotaxime (31%), clindamycin (12%), erythromycin (48%), ofloxacin (0%), tetracycline (42%), TMP/S (85%). Among the 52 DRSP isolates, there were 8 serotypes (23F, 19F, 14, 35B, 6A, 6B, 9A, 9V); the predominant serotypes were 19F, 23F, 6B, and 9V. There were 15 distinguishable PFGE types; two PFGE types (A &B) predominated. PFGE type B isolates correlated with serotype 9V; PFGE type A isolates were serotypes 14, 19F and 23F. Several distinguishable PFGE types were documented among the 6B serotype isolates. PFGE analysis suggests that emergence of DRSP in South Texas involves both clonal strain dissemination and emergence of resistance in distinct strains. Subtyping methods complement epidemiologic studies of DRSP.

Original languageEnglish (US)
Pages (from-to)491
Number of pages1
JournalClinical Infectious Diseases
Volume25
Issue number2
StatePublished - 1997
Externally publishedYes

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Pulsed Field Gel Electrophoresis
Streptococcus pneumoniae
Pharmaceutical Preparations
Population Surveillance
Thymidine Monophosphate
Serotyping
Ofloxacin
Cefotaxime
Clindamycin
Erythromycin
Tetracycline
Penicillins
Epidemiologic Studies
Serogroup
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Immunology

Cite this

Patterson, J. E., Eskew, E. K., Hicks, D. M., Elliott, J., Cetron, M., Schuchat, A., & Jorgensen, J. H. (1997). Epidemiologic typing of Streptococcus pneumoniae invasive isolates from South Texas. Clinical Infectious Diseases, 25(2), 491.

Epidemiologic typing of Streptococcus pneumoniae invasive isolates from South Texas. / Patterson, Jan E; Eskew, E. K.; Hicks, D. M.; Elliott, J.; Cetron, M.; Schuchat, A.; Jorgensen, J. H.

In: Clinical Infectious Diseases, Vol. 25, No. 2, 1997, p. 491.

Research output: Contribution to journalArticle

Patterson, JE, Eskew, EK, Hicks, DM, Elliott, J, Cetron, M, Schuchat, A & Jorgensen, JH 1997, 'Epidemiologic typing of Streptococcus pneumoniae invasive isolates from South Texas', Clinical Infectious Diseases, vol. 25, no. 2, pp. 491.
Patterson, Jan E ; Eskew, E. K. ; Hicks, D. M. ; Elliott, J. ; Cetron, M. ; Schuchat, A. ; Jorgensen, J. H. / Epidemiologic typing of Streptococcus pneumoniae invasive isolates from South Texas. In: Clinical Infectious Diseases. 1997 ; Vol. 25, No. 2. pp. 491.
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