Drug-resistant S. pneumoniae (DRSP) continue to emerge and the epidemiologic typing of DRSP is important in determining mechanisms of spread. Population-based surveillance for invasive DRSP isolates was conducted in the San Antonio area during 1994-96. Susceptibility testing was performed on all isolates. 52 of 522 (10%) invasive pneumococcal isolates were resistant to penicillin (MIC >2 μg/ml) (PRSP). Serotyping and pulsed-field gel electrophoresis (PFGE) typing was performed on PRSP isolates. Per cent resistant of the 52 PRSP to other antibiotics were as follows: cefotaxime (31%), clindamycin (12%), erythromycin (48%), ofloxacin (0%), tetracycline (42%), TMP/S (85%). Among the 52 DRSP isolates, there were 8 serotypes (23F, 19F, 14, 35B, 6A, 6B, 9A, 9V); the predominant serotypes were 19F, 23F, 6B, and 9V. There were 15 distinguishable PFGE types; two PFGE types (A &B) predominated. PFGE type B isolates correlated with serotype 9V; PFGE type A isolates were serotypes 14, 19F and 23F. Several distinguishable PFGE types were documented among the 6B serotype isolates. PFGE analysis suggests that emergence of DRSP in South Texas involves both clonal strain dissemination and emergence of resistance in distinct strains. Subtyping methods complement epidemiologic studies of DRSP.
|Original language||English (US)|
|Number of pages||1|
|Journal||Clinical Infectious Diseases|
|State||Published - Dec 1 1997|
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases