Epidemiologic investigation of tuberculosis in a Mexican population from Chihuahua State, Mexico: A pilot study

Geetha Chittoor, Rector Arya, Vidya S. Farook, Randy David, Sobha Puppala, Roy G. Resendez, Blanca E. Rivera-Chavira, Irene Leal-Berumen, Roberto Zenteno-Cuevas, Juan Carlos López-Alvarenga, Raul A. Bastarrachea, Joanne E. Curran, Subramanian Dhandayuthapani, Lupe Gonzalez, John Blangero, Michael H. Crawford, Esteban M. Vlasich, Luis G. Escobedo, Ravindranath Duggirala

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Tuberculosis (TB) and its co-morbid conditions have become a burden on global health economies. It is well understood that susceptibility of the host to TB infection/disease is influenced by both genetic and environmental factors and their interactions. The aims of this pilot case-control study are to characterize the sociodemographic and environmental factors related to active TB disease (TB/case) and latent TB infection (LTBI/control) status, and to identify risk factors associated with progression from LTBI to TB. We recruited 75 cases with TB (mean age=46.3y; females=41%) and 75 controls with LTBI (mean age=39.0y; females=37%), from the Mestizo population of Cuidad Juárez, Mexico. In addition to the determination of case/control status, information on environmental variables was collected (e.g., socioeconomic status, smoking, alcohol consumption, substance abuse, nutritional status, household demographics, medical histories and presence of type 2 diabetes [T2DM]). The data were analyzed to identify the environmental correlates of TB and LTBI using univariate and multivariate statistical approaches. Following multivariate logistic regression analysis, TB was associated with poor nutrition, T2DM, family history of TB, and non-Chihuahua state of birth. These preliminary findings have relevance to TB control at the Mexico-United States border, and contribute to our future genetic study of TB in Mexicans.

Original languageEnglish (US)
JournalTuberculosis
Volume93
Issue numberSUPPL.
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

Fingerprint

Mexico
Tuberculosis
Population
Latent Tuberculosis
Infection Control
Nutritional Status
Social Class
Alcohol Drinking
Type 2 Diabetes Mellitus
Substance-Related Disorders
Case-Control Studies
Logistic Models
Smoking
Regression Analysis
Demography
Parturition

Keywords

  • Chihuahua (Mexico)
  • Mexico-US border health
  • Nutritional
  • Status
  • Tuberculosis
  • Type 2 Diabetes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Chittoor, G., Arya, R., Farook, V. S., David, R., Puppala, S., Resendez, R. G., ... Duggirala, R. (2013). Epidemiologic investigation of tuberculosis in a Mexican population from Chihuahua State, Mexico: A pilot study. Tuberculosis, 93(SUPPL.). https://doi.org/10.1016/S1472-9792(13)70014-3

Epidemiologic investigation of tuberculosis in a Mexican population from Chihuahua State, Mexico : A pilot study. / Chittoor, Geetha; Arya, Rector; Farook, Vidya S.; David, Randy; Puppala, Sobha; Resendez, Roy G.; Rivera-Chavira, Blanca E.; Leal-Berumen, Irene; Zenteno-Cuevas, Roberto; López-Alvarenga, Juan Carlos; Bastarrachea, Raul A.; Curran, Joanne E.; Dhandayuthapani, Subramanian; Gonzalez, Lupe; Blangero, John; Crawford, Michael H.; Vlasich, Esteban M.; Escobedo, Luis G.; Duggirala, Ravindranath.

In: Tuberculosis, Vol. 93, No. SUPPL., 01.12.2013.

Research output: Contribution to journalArticle

Chittoor, G, Arya, R, Farook, VS, David, R, Puppala, S, Resendez, RG, Rivera-Chavira, BE, Leal-Berumen, I, Zenteno-Cuevas, R, López-Alvarenga, JC, Bastarrachea, RA, Curran, JE, Dhandayuthapani, S, Gonzalez, L, Blangero, J, Crawford, MH, Vlasich, EM, Escobedo, LG & Duggirala, R 2013, 'Epidemiologic investigation of tuberculosis in a Mexican population from Chihuahua State, Mexico: A pilot study', Tuberculosis, vol. 93, no. SUPPL.. https://doi.org/10.1016/S1472-9792(13)70014-3
Chittoor, Geetha ; Arya, Rector ; Farook, Vidya S. ; David, Randy ; Puppala, Sobha ; Resendez, Roy G. ; Rivera-Chavira, Blanca E. ; Leal-Berumen, Irene ; Zenteno-Cuevas, Roberto ; López-Alvarenga, Juan Carlos ; Bastarrachea, Raul A. ; Curran, Joanne E. ; Dhandayuthapani, Subramanian ; Gonzalez, Lupe ; Blangero, John ; Crawford, Michael H. ; Vlasich, Esteban M. ; Escobedo, Luis G. ; Duggirala, Ravindranath. / Epidemiologic investigation of tuberculosis in a Mexican population from Chihuahua State, Mexico : A pilot study. In: Tuberculosis. 2013 ; Vol. 93, No. SUPPL.
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AU - David, Randy

AU - Puppala, Sobha

AU - Resendez, Roy G.

AU - Rivera-Chavira, Blanca E.

AU - Leal-Berumen, Irene

AU - Zenteno-Cuevas, Roberto

AU - López-Alvarenga, Juan Carlos

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AU - Curran, Joanne E.

AU - Dhandayuthapani, Subramanian

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AU - Blangero, John

AU - Crawford, Michael H.

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