Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping

Cory Pfeiffenberger, Tyler Cutforth, Georgia Woods, Jena Yamada, René C. Rentería, David R. Copenhagen, John G. Flanagan, David A. Feldheim

Research output: Contribution to journalArticlepeer-review

130 Scopus citations

Abstract

In mammals, retinal ganglion cell (RGC) projections initially intermingle and then segregate into a stereotyped pattern of eye-specific layers in the dorsal lateral geniculate nucleus (dLGN). Here we found that in mice deficient for ephrin-A2, ephrin-A3 and ephrin-A5, eye-specific inputs segregated but the shape and location of eye-specific layers were profoundly disrupted. In contrast, mice that lacked correlated retinal activity did not segregate eye-specific inputs. Inhibition of correlated neural activity in ephrin mutants led to overlapping retinal projections that were located in inappropriate regions of the dLGN. Thus, ephrin-As and neural activity act together to control patterning of eye-specific retinogeniculate layers.

Original languageEnglish (US)
Pages (from-to)1022-1027
Number of pages6
JournalNature Neuroscience
Volume8
Issue number8
DOIs
StatePublished - Aug 2005
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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