Abstract
We studied the enteric absorption of ciprofloxacin immediately following major abdominal surgery to determine if this drug could replace parenteral agents. Nine critically ill subjects received ciprofloxacin, 750 mg, every 12 h for 48 h via nasogastric tube. Drug concentrations were measured after the first and fourth doses. There was insignificant absorption after the initial dose, Cmax = 0.6 ± 0.6 (mg/L) and AUCo-12 = 3.5 ± 3.2 (mg.h/L). Unfortunately, serum ciprofloxacin concentrations were also minimally detectable in three of nine subjects after the fourth dose. Enteric absorption of ciprofloxacin, therefore, was erratic and unpredictable in critically ill patients following major abdominal surgery.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 717-721 |
| Number of pages | 5 |
| Journal | Journal of Antimicrobial Chemotherapy |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Physiology (medical)
- Infectious Diseases
- Pharmacology (medical)
- Pharmacology
- Microbiology
Cite this
Enteric absorption of ciprofloxacin during the immediate postoperative period. / Cohn, Stephen M.; Cohn, Kelly A.; Rafferty, Michael J.; Smith, Andrew H.; Degutis, Linda C.; Kowalsky, Steven F.; Shah, Anita.
In: Journal of Antimicrobial Chemotherapy, Vol. 36, No. 4, 10.1995, p. 717-721.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enteric absorption of ciprofloxacin during the immediate postoperative period
AU - Cohn, Stephen M.
AU - Cohn, Kelly A.
AU - Rafferty, Michael J.
AU - Smith, Andrew H.
AU - Degutis, Linda C.
AU - Kowalsky, Steven F.
AU - Shah, Anita
PY - 1995/10
Y1 - 1995/10
N2 - We studied the enteric absorption of ciprofloxacin immediately following major abdominal surgery to determine if this drug could replace parenteral agents. Nine critically ill subjects received ciprofloxacin, 750 mg, every 12 h for 48 h via nasogastric tube. Drug concentrations were measured after the first and fourth doses. There was insignificant absorption after the initial dose, Cmax = 0.6 ± 0.6 (mg/L) and AUCo-12 = 3.5 ± 3.2 (mg.h/L). Unfortunately, serum ciprofloxacin concentrations were also minimally detectable in three of nine subjects after the fourth dose. Enteric absorption of ciprofloxacin, therefore, was erratic and unpredictable in critically ill patients following major abdominal surgery.
AB - We studied the enteric absorption of ciprofloxacin immediately following major abdominal surgery to determine if this drug could replace parenteral agents. Nine critically ill subjects received ciprofloxacin, 750 mg, every 12 h for 48 h via nasogastric tube. Drug concentrations were measured after the first and fourth doses. There was insignificant absorption after the initial dose, Cmax = 0.6 ± 0.6 (mg/L) and AUCo-12 = 3.5 ± 3.2 (mg.h/L). Unfortunately, serum ciprofloxacin concentrations were also minimally detectable in three of nine subjects after the fourth dose. Enteric absorption of ciprofloxacin, therefore, was erratic and unpredictable in critically ill patients following major abdominal surgery.
UR - http://www.scopus.com/inward/record.url?scp=0028857683&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028857683&partnerID=8YFLogxK
U2 - 10.1093/jac/36.4.717
DO - 10.1093/jac/36.4.717
M3 - Article
C2 - 8591948
AN - SCOPUS:0028857683
VL - 36
SP - 717
EP - 721
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
SN - 0305-7453
IS - 4
ER -