Enteric absorption of ciprofloxacin during the immediate postoperative period

Stephen M. Cohn, Kelly A. Cohn, Michael J. Rafferty, Andrew H. Smith, Linda C. Degutis, Steven F. Kowalsky, Anita Shah

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We studied the enteric absorption of ciprofloxacin immediately following major abdominal surgery to determine if this drug could replace parenteral agents. Nine critically ill subjects received ciprofloxacin, 750 mg, every 12 h for 48 h via nasogastric tube. Drug concentrations were measured after the first and fourth doses. There was insignificant absorption after the initial dose, Cmax = 0.6 ± 0.6 (mg/L) and AUCo-12 = 3.5 ± 3.2 (mg.h/L). Unfortunately, serum ciprofloxacin concentrations were also minimally detectable in three of nine subjects after the fourth dose. Enteric absorption of ciprofloxacin, therefore, was erratic and unpredictable in critically ill patients following major abdominal surgery.

Original languageEnglish (US)
Pages (from-to)717-721
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume36
Issue number4
DOIs
StatePublished - Oct 1995
Externally publishedYes

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Ciprofloxacin
Postoperative Period
Surgery
Dose
Absorption
Drugs
Critical Illness
Immediately
Tube
Pharmaceutical Preparations
Serum

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)
  • Pharmacology
  • Microbiology

Cite this

Cohn, S. M., Cohn, K. A., Rafferty, M. J., Smith, A. H., Degutis, L. C., Kowalsky, S. F., & Shah, A. (1995). Enteric absorption of ciprofloxacin during the immediate postoperative period. Journal of Antimicrobial Chemotherapy, 36(4), 717-721. https://doi.org/10.1093/jac/36.4.717

Enteric absorption of ciprofloxacin during the immediate postoperative period. / Cohn, Stephen M.; Cohn, Kelly A.; Rafferty, Michael J.; Smith, Andrew H.; Degutis, Linda C.; Kowalsky, Steven F.; Shah, Anita.

In: Journal of Antimicrobial Chemotherapy, Vol. 36, No. 4, 10.1995, p. 717-721.

Research output: Contribution to journalArticle

Cohn, SM, Cohn, KA, Rafferty, MJ, Smith, AH, Degutis, LC, Kowalsky, SF & Shah, A 1995, 'Enteric absorption of ciprofloxacin during the immediate postoperative period', Journal of Antimicrobial Chemotherapy, vol. 36, no. 4, pp. 717-721. https://doi.org/10.1093/jac/36.4.717
Cohn SM, Cohn KA, Rafferty MJ, Smith AH, Degutis LC, Kowalsky SF et al. Enteric absorption of ciprofloxacin during the immediate postoperative period. Journal of Antimicrobial Chemotherapy. 1995 Oct;36(4):717-721. https://doi.org/10.1093/jac/36.4.717
Cohn, Stephen M. ; Cohn, Kelly A. ; Rafferty, Michael J. ; Smith, Andrew H. ; Degutis, Linda C. ; Kowalsky, Steven F. ; Shah, Anita. / Enteric absorption of ciprofloxacin during the immediate postoperative period. In: Journal of Antimicrobial Chemotherapy. 1995 ; Vol. 36, No. 4. pp. 717-721.
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