TY - JOUR
T1 - Enriched Environment Contributes to the Recovery from Neurotoxin-Induced Parkinson’s Disease Pathology
AU - Alcalá-Zúniga, Daphne
AU - Espinoza-Torres, Erika
AU - Das, Ranjit Kumar
AU - Vargas, Magaly
AU - Maldonado, Oscar
AU - Benavides, Omar
AU - Manojkumar, Arvind
AU - de la Garza, Roberto
AU - Davila, Natalia
AU - Perez, Isaac
AU - Martinez, Alejandro Hernandez
AU - Roy, Deepa
AU - López-Juárez, Alejandro
AU - Zarei, Masoud M.
AU - Baker, Kelsey A.
AU - Gil, Mario
AU - Rodrigo, Hansapani
AU - de Erausquin, Gabriel A.
AU - Roy, Upal
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/9
Y1 - 2024/9
N2 - Parkinson’s disease (PD) is a neurological disorder that affects dopaminergic neurons. The lack of understanding of the underlying molecular mechanisms of PD pathology makes treating it a challenge. Several pieces of evidence support the protective role of enriched environment (EE) and exercise on dopaminergic neurons. The specific aspect(s) of neuroprotection after exposure to EE have not been identified. Therefore, we have investigated the protective role of EE on dopamine dysregulation and subsequent downregulation of DJ1 protein using in vitro and in vivo models of PD. Our study for the first time demonstrated that DJ1 expression has a direct correlation with dopamine downregulation in PD models and exposure to EE has a significant impact on improving the behavioral changes in PD mice. This research provides evidence that exercise in EE has a positive effect on PD without interfering with the current line of therapy.
AB - Parkinson’s disease (PD) is a neurological disorder that affects dopaminergic neurons. The lack of understanding of the underlying molecular mechanisms of PD pathology makes treating it a challenge. Several pieces of evidence support the protective role of enriched environment (EE) and exercise on dopaminergic neurons. The specific aspect(s) of neuroprotection after exposure to EE have not been identified. Therefore, we have investigated the protective role of EE on dopamine dysregulation and subsequent downregulation of DJ1 protein using in vitro and in vivo models of PD. Our study for the first time demonstrated that DJ1 expression has a direct correlation with dopamine downregulation in PD models and exposure to EE has a significant impact on improving the behavioral changes in PD mice. This research provides evidence that exercise in EE has a positive effect on PD without interfering with the current line of therapy.
KW - Cell model
KW - DJ1
KW - Dopamine
KW - Enriched environment
KW - Parkinson’s disease
KW - SH-SY5Y
KW - The mouse model
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U2 - 10.1007/s12035-024-03951-w
DO - 10.1007/s12035-024-03951-w
M3 - Article
C2 - 38349515
AN - SCOPUS:85185113301
SN - 0893-7648
VL - 61
SP - 6734
EP - 6753
JO - Molecular Neurobiology
JF - Molecular Neurobiology
IS - 9
ER -