Enriched Environment Contributes to the Recovery from Neurotoxin-Induced Parkinson’s Disease Pathology

Daphne Alcalá-Zúniga, Erika Espinoza-Torres, Ranjit Kumar Das, Magaly Vargas, Oscar Maldonado, Omar Benavides, Arvind Manojkumar, Roberto de la Garza, Natalia Davila, Isaac Perez, Alejandro Hernandez Martinez, Deepa Roy, Alejandro López-Juárez, Masoud M. Zarei, Kelsey A. Baker, Mario Gil, Hansapani Rodrigo, Gabriel A. de Erausquin, Upal Roy

Research output: Contribution to journalArticlepeer-review

Abstract

Parkinson’s disease (PD) is a neurological disorder that affects dopaminergic neurons. The lack of understanding of the underlying molecular mechanisms of PD pathology makes treating it a challenge. Several pieces of evidence support the protective role of enriched environment (EE) and exercise on dopaminergic neurons. The specific aspect(s) of neuroprotection after exposure to EE have not been identified. Therefore, we have investigated the protective role of EE on dopamine dysregulation and subsequent downregulation of DJ1 protein using in vitro and in vivo models of PD. Our study for the first time demonstrated that DJ1 expression has a direct correlation with dopamine downregulation in PD models and exposure to EE has a significant impact on improving the behavioral changes in PD mice. This research provides evidence that exercise in EE has a positive effect on PD without interfering with the current line of therapy.

Original languageEnglish (US)
JournalMolecular Neurobiology
DOIs
StateAccepted/In press - 2024

Keywords

  • Cell model
  • DJ1
  • Dopamine
  • Enriched environment
  • Parkinson’s disease
  • SH-SY5Y
  • The mouse model

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience
  • Neuroscience (miscellaneous)

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