@inproceedings{9633b02a2e2542ecad5510c99090a6c0,
title = "ENIGMA military brain injury: A coordinated meta-analysis of diffusion MRI from multiple cohorts",
abstract = "Traumatic brain injury (TBI) is a significant cause of morbidity in military Veterans and Service Members. While most individuals recover fully from mild injuries within weeks, some continue to experience symptoms including headaches, disrupted sleep, and other cognitive, behavioral or physical symptoms. Diffusion magnetic resonance imaging (dMRI) shows promise in identifying areas of structural disruption and predicting outcomes. Although some studies suggest widespread structural disruption after brain injury, dMRI studies of military brain injury have yielded mixed results so far, perhaps due to the subtlety of mild injury, individual differences in injury location, severity and mechanism, and co-morbidity with other disorders such as post-traumatic stress disorder (PTSD), depression, and substance abuse. We present preliminary dMRI results from the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) military brain injury working group. We found higher fractional anisotropy (FA) in participants with a history of TBI. Understanding the injury and recovery process, along with factors that influence these, will lead to improved diagnosis and treatment.",
keywords = "Blast, Diffusion MRI, ENIGMA, Military, Traumatic brain injury",
author = "Dennis, {Emily L.} and Wilde, {Elisabeth A.} and Newsome, {Mary R.} and Scheibel, {Randall S.} and Maya Troyanskaya and Carmen Velez and Wade, {Benjamin S.C.} and Drennon, {Ann Marie} and York, {Gerald E.} and Bigler, {Erin D.} and Abildskov, {Tracy J.} and Taylor, {Brian A.} and Jaramillo, {Carlos A.} and Blessen Eapen and Heather Belanger and Vikash Gupta and Rajendra Morey and Courtney Haswell and Levin, {Harvey S.} and Hinds, {Sidney R.} and Walker, {William C.} and Thompson, {Paul M.} and Tate, {David F.}",
note = "Funding Information: 1Imaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, CA, USA; 2Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA;3Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA; 4Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA; 5Department of Neurology, University of Utah, Salt Lake City, UT, USA; 6University of Missouri-St. Louis, St. Louis, MO, USA; 7Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, UCLA, Los Angeles, CA, USA; 8Defense and Veterans Brain Injury Center, San Antonio, TX, USA; 9Alaska Radiology Associates, Anchorage, AK, USA 10Department of Psychology and Neuroscience, Brigham Young University, Provo, UT, USA; 11Department of Radiology, Baylor College of Medicine, Houston, TX, USA; 12Polytrauma Rehabilitation Center, South Texas Veterans Health Care System, San Antonio, TX; 13James A. Haley Veterans Hospital, Tampa, FL, USA; 14University of South Florida, Tampa, FL, USA; 15Psychiatry, Duke University, Durham, NC; 16Department of Defense/United States Army Medical Research and Materiel Command; 17Department of Physical Medicine & Rehabilitation, Virginia Commonwealth University, Richmond VA; 18Hunter Holmes McGuire VAMC, Richmond VA; 19Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology, USC, Los Angeles, CA; 15th IEEE International Symposium on Biomedical Imaging, ISBI 2018 ; Conference date: 04-04-2018 Through 07-04-2018",
year = "2018",
month = may,
day = "23",
doi = "10.1109/ISBI.2018.8363830",
language = "English (US)",
series = "Proceedings - International Symposium on Biomedical Imaging",
publisher = "IEEE Computer Society",
pages = "1386--1389",
booktitle = "2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018",
address = "United States",
}