The concentrated Perflubron emulsion, Oxygent, in combination with breathing a 95% oxygen atmosphere, significantly enhanced the response of the murine Lewis lung carcinoma to fractionated radiation therapy. Administration of 4 to 12 g PFC/kg was most effective if administered prior to each x-ray fraction, however, alternated day and even once weekly administration of 8 or 12 PFC/kg and 95% oxygen breathing with each x-ray fraction resulted in significant improvements in tumor growth delay.
|Original language||English (US)|
|Number of pages||4|
|Journal||Biomaterials, Artificial Cells and Immobilization Biotechnology|
|Issue number||4 --Feb|
|State||Published - Jan 1992|
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