Enhancement op fractionated radiation therapy by an experimental concentrated perflubron emulsion (oxygent) in the lewis lung carcinoma

Beverly A. Teicher, Terence S. Herman, Krishna Menon

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The concentrated Perflubron emulsion, Oxygent, in combination with breathing a 95% oxygen atmosphere, significantly enhanced the response of the murine Lewis lung carcinoma to fractionated radiation therapy. Administration of 4 to 12 g PFC/kg was most effective if administered prior to each x-ray fraction, however, alternated day and even once weekly administration of 8 or 12 PFC/kg and 95% oxygen breathing with each x-ray fraction resulted in significant improvements in tumor growth delay.

Original languageEnglish (US)
Pages (from-to)899-902
Number of pages4
JournalBiomaterials, Artificial Cells and Immobilization Biotechnology
Volume20
Issue number4 --Feb
DOIs
StatePublished - Jan 1992
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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