Abstract
Dimethyl sulfoxide (DMSO) has many biological effects, which include enhancement of polyethylene glycol (PEG) -mediated cell fusion, induction of cell differentiation in erythroleukemia and other cell systems, and cryoprotection of cells from freezing damage. In this study, compounds which induce erythroleukemia cell differentiation were tested for their ability to enhance PEG-mediated cell fusion. It was found that many compounds which induce erythroleukemia cell differentiation also promote cell membrane fusion as well as protect cells against freezing damage. Hence, many inducers of erythroleukemia cell differentiation have direct and similar effects on cell membranes. This study also demonstrates previously unrecognized effects of cryoprotective agents and cell fusogens on the differentiated state of cultured cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 723-730 |
| Number of pages | 8 |
| Journal | Somatic Cell Genetics |
| Volume | 8 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 1982 |
| Externally published | Yes |
ASJC Scopus subject areas
- Genetics