Enhancement of hepatitis B virus replication by its X protein in transgenic mice

Zhenming Xu, T. S.Benedict Yen, Lanying Wu, Charles R. Madden, Wenjie Tan, Betty L. Slagle, Jing Hsiung Ou

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109 Scopus citations

Abstract

Hepatitis B virus (HBV) X gene encodes a multifunctional protein that can regulate cellular signaling pathways, interact with cellular transcription factors, and induce hepatocellular oncogenesis. In spite of its diverse activities, the precise role of the X protein in the viral life cycle of HBV remains unclear. To investigate this question, we have produced transgenic mice that carry either the wild-type HBV genome or a mutated HBV genome incapable of expressing the 16.5-kDa X protein. Our results indicate that while the X protein is not absolutely essential for HBV replication or its maturation in transgenic mice, it can enhance viral replication, apparently by activating viral gene expression. These results demonstrate a transactivation role of the X protein in HBV replication in transgenic mice.

Original languageEnglish (US)
Pages (from-to)2579-2584
Number of pages6
JournalJournal of Virology
Volume76
Issue number5
DOIs
Publication statusPublished - Feb 26 2002

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Xu, Z., Yen, T. S. B., Wu, L., Madden, C. R., Tan, W., Slagle, B. L., & Ou, J. H. (2002). Enhancement of hepatitis B virus replication by its X protein in transgenic mice. Journal of Virology, 76(5), 2579-2584. https://doi.org/10.1128/jvi.76.5.2579-2584.2002