Enhancement of brain pO2 during cardiopulmonary bypass using a hyperosmolar oxygen carrying solution

T. M. Runge, J. W. McGinity, S. E. Frisbee, J. C. Briceno, S. E. Ottmers, John H Calhoon, C. B. Hantler, D. L. Korvick, J. R. Ybarra

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

During the past decade a new syndrome has been recognized: cerebral hypoxia secondary to cardiopulmonary bypass, resulting in impairment of cognitive memory. The incidence of the syndrome appears to be no less that 30% in patients over 65 years of age undergoing cardiac surgery. There are several factors contributing to hypoxia produced by cardiopulmonary bypass. One of these factors is crystalloid pump prime and replacement solutions devoid of (1) oxygen carrying capacity and (2) devoid of protein and its colloid osmotic pressure. This shortcoming of cardiopulmonary crystalloid solutions is partially responsible for two of the three major pathologic effects of cardiopulmonary bypass: (1) hypoxia (2) interstitial fluid accumulation (anasarca, water-logging, edema). This report describes an oxygen carrying hyperosmolar solution which enhances brain pO2 and diminishes interstitial fluid accumulation. This blood substitute consists of perfluorcarbons and saccharides, but could consist of a hemoglobin variant plus hyperosmolar ingredients other than saccharides. The advantage of perfluorochemical is its ability to access small channels and to be centrifuged off the patient post-operatively with a cell saver. The advantage of saccharides is that they can be metabolized by the patient for energy, and they produce a moderate diuresis coming off bypass.

Original languageEnglish (US)
Pages (from-to)297-308
Number of pages12
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume25
Issue number3
StatePublished - May 1997

Fingerprint

Cardiopulmonary Bypass
Brain
Extracellular Fluid
Oxygen
Blood Substitutes
Fluids
Edema
Colloids
Blood substitutes
Surgery
Brain Hypoxia
Hemoglobins
Aptitude
Diuresis
Hemoglobin
Osmotic Pressure
Conservation of Natural Resources
Pumps
Data storage equipment
Thoracic Surgery

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Biomaterials
  • Hematology

Cite this

Runge, T. M., McGinity, J. W., Frisbee, S. E., Briceno, J. C., Ottmers, S. E., Calhoon, J. H., ... Ybarra, J. R. (1997). Enhancement of brain pO2 during cardiopulmonary bypass using a hyperosmolar oxygen carrying solution. Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, 25(3), 297-308.

Enhancement of brain pO2 during cardiopulmonary bypass using a hyperosmolar oxygen carrying solution. / Runge, T. M.; McGinity, J. W.; Frisbee, S. E.; Briceno, J. C.; Ottmers, S. E.; Calhoon, John H; Hantler, C. B.; Korvick, D. L.; Ybarra, J. R.

In: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, Vol. 25, No. 3, 05.1997, p. 297-308.

Research output: Contribution to journalArticle

Runge, TM, McGinity, JW, Frisbee, SE, Briceno, JC, Ottmers, SE, Calhoon, JH, Hantler, CB, Korvick, DL & Ybarra, JR 1997, 'Enhancement of brain pO2 during cardiopulmonary bypass using a hyperosmolar oxygen carrying solution', Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, vol. 25, no. 3, pp. 297-308.
Runge, T. M. ; McGinity, J. W. ; Frisbee, S. E. ; Briceno, J. C. ; Ottmers, S. E. ; Calhoon, John H ; Hantler, C. B. ; Korvick, D. L. ; Ybarra, J. R. / Enhancement of brain pO2 during cardiopulmonary bypass using a hyperosmolar oxygen carrying solution. In: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 1997 ; Vol. 25, No. 3. pp. 297-308.
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