Enhancement by perflusion emulsion (oxygent) and carbogen breathing of the tumor growth delay of the fsaiic fibrosarcoma after treatment with antitumor alkylating agents

Sylvia A. Holden, Beverly A. Teicher, Chul Ha, Gulshan Ara, Terence S. Herman

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Many anticancer drugs require oxygen to be cytotoxic, or are selectively cytotoxic toward cells under oxygenated conditions. The effects of the dilute perfluorochemical emulsion Fluosol-DA with a wide variety of chemotherapeutic agents have been explored; however, it has not been possible to determine the optimal level of circulating perfluorochemical emulsion with anticancer drugs because the volume of Fluosol that my be administered in limited. Using a concentrated 90% Perflubron emulsion, Oxygent, a wide range of perfluorochemical emulsion doses have been examined in combination with melphalan, cyclophosphamide and BCNU in a murine solid tumor model. When Oxygent was administered by injection i.v. just prior to the injection of melphalan (10 mg/kg), the greatest tumor growth delays were obtained with Oxygent levels between 4 and 12 g PFC/kg. With each of these drugs the greatest tumor growth delays were obtained when the drug was prepared in the emulsion and the combination injected i.v. In each case, each dose of drug was followed by 6 h. of breathing carbogen.

Original languageEnglish (US)
Pages (from-to)895-898
Number of pages4
JournalBiomaterials, Artificial Cells and Immobilization Biotechnology
Volume20
Issue number4 --Feb
DOIs
StatePublished - Jan 1992
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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