Enhancement by food restriction of liver protein synthesis in the aging Fischer 344 rat

W. F. Ward

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Age-related changes in liver protein synthesis of ad libitum fed and food-restricted SPF Fischer 344 rats have been measured. In ad libitum fed animals, valine incorporation increased from 3 to 6 mo of age, decreased to the 3-mo level at 12 mo, remained relatively constant through 18 mo, and then declined further at 24 mo of age. By 24 mo valine incorporation was 30% of the 6-mo value. Food restriction had no effect at 3 mo of age (6 wk of restriction) but at 6 mo the rate of valine incorporation was 35% greater than the control, an increment that was maintained throughout the life of the animal. Therefore, although food restriction does not prevent the age-related decline in protein synthesis, it does maintain the rate of liver valine incorporation at levels greater than those observed in the liver of the ad libitum fed animal.

Original languageEnglish (US)
Pages (from-to)B50-B53
JournalJournals of Gerontology
Issue number2
StatePublished - Jan 1 1988


ASJC Scopus subject areas

  • Aging

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