Enhanced tumor metastases upon drug delivery in cross-linked albumin beads

Mary Pat Moyer; Anna Armstrong; Juan Parra; Donna Escobar

doi:10.1007/BF00053474

Enhanced tumor metastases upon drug delivery in cross-linked albumin beads

Mary Pat Moyer, Anna Armstrong, Juan Parra, Donna Escobar

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Growth of the murine hepatoma H6 was significantly suppressed by amiloride, a sodium influx inhibitor. Primary tumor growth inhibition was augmented by loading the drug into cross-linked albumin carriers, but lung metastases were enhanced. These results emphasize the importance of using metastatic tumor models when testing new drugs and/or alternative modes of drug delivery.

Original language	English (US)
Pages (from-to)	63-70
Number of pages	8
Journal	Clinical and Experimental Metastasis
Volume	4
Issue number	1
DOIs	https://doi.org/10.1007/BF00053474
State	Published - Mar 1986

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/BF00053474

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title = "Enhanced tumor metastases upon drug delivery in cross-linked albumin beads",

abstract = "Growth of the murine hepatoma H6 was significantly suppressed by amiloride, a sodium influx inhibitor. Primary tumor growth inhibition was augmented by loading the drug into cross-linked albumin carriers, but lung metastases were enhanced. These results emphasize the importance of using metastatic tumor models when testing new drugs and/or alternative modes of drug delivery.",

author = "Moyer, {Mary Pat} and Anna Armstrong and Juan Parra and Donna Escobar",

year = "1986",

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AB - Growth of the murine hepatoma H6 was significantly suppressed by amiloride, a sodium influx inhibitor. Primary tumor growth inhibition was augmented by loading the drug into cross-linked albumin carriers, but lung metastases were enhanced. These results emphasize the importance of using metastatic tumor models when testing new drugs and/or alternative modes of drug delivery.

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Enhanced tumor metastases upon drug delivery in cross-linked albumin beads

Abstract

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