Abstract
Objective: Observe the effect of silver-nylon (SN) dressing and direct electric current on healing of meshed autoepidermal/allodermal composite skin grafts (MCSGs) in allosensitized rats. Materials and Methods: MCSGs were placed on experimental animals 28 to 30 days after placement of sensitizing allografts. MCSGs and control allografts were covered with either Vaseline gauze (VG) or SN; direct current, 40 μA, was applied for 5 days to some of the SN-dressed wounds (SNDCs). Measurements and Main Results: Second set rejection of MCSG was not observed. SN- and SNDC-treated grafts showed expansion of the meshed autoepidermis with complete epithelialization within 3 weeks. VG-covered wounds developed areas of open granulation and were not completely epithelialized at 3 months. Both SN and SNDC reduced wound contraction when compared to VG (SN versus VG p < 0.02, SNDC versus VG p < 0.008). MCSG was found to be of low alloantigenicity in that it did not induce second set rejection of subsequent skin allograft. Conclusions: SN dressings enhanced survival of meshed composite skin grafts.
Original language | English (US) |
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Pages (from-to) | 273-278 |
Number of pages | 6 |
Journal | Journal of Trauma - Injury, Infection and Critical Care |
Volume | 39 |
Issue number | 2 |
DOIs | |
State | Published - 1995 |
Externally published | Yes |
Keywords
- Direct current
- Meshed autoepidermal-allodermal composite skin graft
- Silver- nylon
- Wound contraction
ASJC Scopus subject areas
- Surgery
- Critical Care and Intensive Care Medicine