Enhanced survival of autoepidermal-allodermal composite grafts in allosensitized animals by use of Silver-Nylon dressings and direct current

C. S. Chu, A. T. McManus, N. P. Matylevich, A. D. Mason, B. A. Pruitt, G. D. Warden, A. A. Meyer, R. G. Tompkins

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19 Scopus citations

Abstract

Objective: Observe the effect of silver-nylon (SN) dressing and direct electric current on healing of meshed autoepidermal/allodermal composite skin grafts (MCSGs) in allosensitized rats. Materials and Methods: MCSGs were placed on experimental animals 28 to 30 days after placement of sensitizing allografts. MCSGs and control allografts were covered with either Vaseline gauze (VG) or SN; direct current, 40 μA, was applied for 5 days to some of the SN-dressed wounds (SNDCs). Measurements and Main Results: Second set rejection of MCSG was not observed. SN- and SNDC-treated grafts showed expansion of the meshed autoepidermis with complete epithelialization within 3 weeks. VG-covered wounds developed areas of open granulation and were not completely epithelialized at 3 months. Both SN and SNDC reduced wound contraction when compared to VG (SN versus VG p < 0.02, SNDC versus VG p < 0.008). MCSG was found to be of low alloantigenicity in that it did not induce second set rejection of subsequent skin allograft. Conclusions: SN dressings enhanced survival of meshed composite skin grafts.

Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume39
Issue number2
DOIs
StatePublished - Sep 12 1995

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Keywords

  • Direct current
  • Meshed autoepidermal-allodermal composite skin graft
  • Silver- nylon
  • Wound contraction

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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