Enhanced survival of autoepidermal-allodermal composite grafts in allosensitized animals by use of Silver-Nylon dressings and direct current

C. S. Chu; A. T. McManus; N. P. Matylevich; A. D. Mason; B. A. Pruitt; G. D. Warden; A. A. Meyer; R. G. Tompkins

doi:10.1097/00005373-199508000-00014

Enhanced survival of autoepidermal-allodermal composite grafts in allosensitized animals by use of Silver-Nylon dressings and direct current

C. S. Chu, A. T. McManus, N. P. Matylevich, A. D. Mason, B. A. Pruitt, G. D. Warden, A. A. Meyer, R. G. Tompkins

Surgery

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Objective: Observe the effect of silver-nylon (SN) dressing and direct electric current on healing of meshed autoepidermal/allodermal composite skin grafts (MCSGs) in allosensitized rats. Materials and Methods: MCSGs were placed on experimental animals 28 to 30 days after placement of sensitizing allografts. MCSGs and control allografts were covered with either Vaseline gauze (VG) or SN; direct current, 40 μA, was applied for 5 days to some of the SN-dressed wounds (SNDCs). Measurements and Main Results: Second set rejection of MCSG was not observed. SN- and SNDC-treated grafts showed expansion of the meshed autoepidermis with complete epithelialization within 3 weeks. VG-covered wounds developed areas of open granulation and were not completely epithelialized at 3 months. Both SN and SNDC reduced wound contraction when compared to VG (SN versus VG p < 0.02, SNDC versus VG p < 0.008). MCSG was found to be of low alloantigenicity in that it did not induce second set rejection of subsequent skin allograft. Conclusions: SN dressings enhanced survival of meshed composite skin grafts.

Original language	English (US)
Pages (from-to)	273-278
Number of pages	6
Journal	Journal of Trauma - Injury, Infection and Critical Care
Volume	39
Issue number	2
DOIs	https://doi.org/10.1097/00005373-199508000-00014
State	Published - Sep 12 1995

Keywords

Direct current
Meshed autoepidermal-allodermal composite skin graft
Silver- nylon
Wound contraction

ASJC Scopus subject areas

Surgery
Critical Care and Intensive Care Medicine

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10.1097/00005373-199508000-00014

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Chu, C. S., McManus, A. T., Matylevich, N. P., Mason, A. D., Pruitt, B. A., Warden, G. D., Meyer, A. A., & Tompkins, R. G. (1995). Enhanced survival of autoepidermal-allodermal composite grafts in allosensitized animals by use of Silver-Nylon dressings and direct current. Journal of Trauma - Injury, Infection and Critical Care, 39(2), 273-278. https://doi.org/10.1097/00005373-199508000-00014

Enhanced survival of autoepidermal-allodermal composite grafts in allosensitized animals by use of Silver-Nylon dressings and direct current. / Chu, C. S.; McManus, A. T.; Matylevich, N. P.; Mason, A. D.; Pruitt, B. A.; Warden, G. D.; Meyer, A. A.; Tompkins, R. G.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 39, No. 2, 12.09.1995, p. 273-278.

Research output: Contribution to journal › Article › peer-review

Chu, CS, McManus, AT, Matylevich, NP, Mason, AD, Pruitt, BA, Warden, GD, Meyer, AA & Tompkins, RG 1995, 'Enhanced survival of autoepidermal-allodermal composite grafts in allosensitized animals by use of Silver-Nylon dressings and direct current', Journal of Trauma - Injury, Infection and Critical Care, vol. 39, no. 2, pp. 273-278. https://doi.org/10.1097/00005373-199508000-00014

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abstract = "Objective: Observe the effect of silver-nylon (SN) dressing and direct electric current on healing of meshed autoepidermal/allodermal composite skin grafts (MCSGs) in allosensitized rats. Materials and Methods: MCSGs were placed on experimental animals 28 to 30 days after placement of sensitizing allografts. MCSGs and control allografts were covered with either Vaseline gauze (VG) or SN; direct current, 40 μA, was applied for 5 days to some of the SN-dressed wounds (SNDCs). Measurements and Main Results: Second set rejection of MCSG was not observed. SN- and SNDC-treated grafts showed expansion of the meshed autoepidermis with complete epithelialization within 3 weeks. VG-covered wounds developed areas of open granulation and were not completely epithelialized at 3 months. Both SN and SNDC reduced wound contraction when compared to VG (SN versus VG p < 0.02, SNDC versus VG p < 0.008). MCSG was found to be of low alloantigenicity in that it did not induce second set rejection of subsequent skin allograft. Conclusions: SN dressings enhanced survival of meshed composite skin grafts.",

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AU - Matylevich, N. P.

AU - Mason, A. D.

AU - Pruitt, B. A.

AU - Warden, G. D.

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AB - Objective: Observe the effect of silver-nylon (SN) dressing and direct electric current on healing of meshed autoepidermal/allodermal composite skin grafts (MCSGs) in allosensitized rats. Materials and Methods: MCSGs were placed on experimental animals 28 to 30 days after placement of sensitizing allografts. MCSGs and control allografts were covered with either Vaseline gauze (VG) or SN; direct current, 40 μA, was applied for 5 days to some of the SN-dressed wounds (SNDCs). Measurements and Main Results: Second set rejection of MCSG was not observed. SN- and SNDC-treated grafts showed expansion of the meshed autoepidermis with complete epithelialization within 3 weeks. VG-covered wounds developed areas of open granulation and were not completely epithelialized at 3 months. Both SN and SNDC reduced wound contraction when compared to VG (SN versus VG p < 0.02, SNDC versus VG p < 0.008). MCSG was found to be of low alloantigenicity in that it did not induce second set rejection of subsequent skin allograft. Conclusions: SN dressings enhanced survival of meshed composite skin grafts.

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Enhanced survival of autoepidermal-allodermal composite grafts in allosensitized animals by use of Silver-Nylon dressings and direct current

Abstract

Keywords

ASJC Scopus subject areas

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