Enhanced release of immunoreactive CGRP and substance P from spinal dorsal horn slices occurs during carrageenan inflammation

Mary G. Garry, Kenneth M Hargreaves

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

In vitro superfusion was used to examine the effect of inflammation on the release of immunoreactive calcitonin gene-related peptide (iCGRP) and substance P(iSP) from the dorsal horn of rats. Three hours after carrageenan, hindpaws exhibited hyperalgesia, edema, and hyperthermia. Spontaneous and capsaicin-evoked release of iCGRP and iSP were significantly increased following inflammation. The enhanced release of iCGRP and iSP in the dorsal horn may serve as a biochemical marker for the development of hyperalgesia.

Original languageEnglish (US)
Pages (from-to)139-142
Number of pages4
JournalBrain Research
Volume582
Issue number1
DOIs
StatePublished - Jun 5 1992
Externally publishedYes

Fingerprint

Calcitonin Gene-Related Peptide
Carrageenan
Substance P
Hyperalgesia
Inflammation
Capsaicin
Edema
Fever
Biomarkers
peptide P
Spinal Cord Dorsal Horn

Keywords

  • Calcitonin gene-related peptide
  • Carrageenan
  • Dorsal horn
  • Inflammation
  • Pain
  • Spinal cord
  • Substance P

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Enhanced release of immunoreactive CGRP and substance P from spinal dorsal horn slices occurs during carrageenan inflammation. / Garry, Mary G.; Hargreaves, Kenneth M.

In: Brain Research, Vol. 582, No. 1, 05.06.1992, p. 139-142.

Research output: Contribution to journalArticle

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