Abstract
In vitro superfusion was used to examine the effect of inflammation on the release of immunoreactive calcitonin gene-related peptide (iCGRP) and substance P(iSP) from the dorsal horn of rats. Three hours after carrageenan, hindpaws exhibited hyperalgesia, edema, and hyperthermia. Spontaneous and capsaicin-evoked release of iCGRP and iSP were significantly increased following inflammation. The enhanced release of iCGRP and iSP in the dorsal horn may serve as a biochemical marker for the development of hyperalgesia.
Original language | English (US) |
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Pages (from-to) | 139-142 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 582 |
Issue number | 1 |
DOIs | |
State | Published - Jun 5 1992 |
Externally published | Yes |
Keywords
- Calcitonin gene-related peptide
- Carrageenan
- Dorsal horn
- Inflammation
- Pain
- Spinal cord
- Substance P
ASJC Scopus subject areas
- Clinical Neurology
- Molecular Biology
- General Neuroscience
- Developmental Biology