Enflurane and uterine contractility in rabbits

D. J. Jones, B. J. Hodgson, L. C. Stehling, H. L. Zauder

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Abstract

The effect of enflurane on uterine contractility was studied in sexually mature rabbits in which intrauterine balloon catheters had been implanted. Three animal groups were studied: untreated; treated with estrogen-progesterone; and 27-28 days pregnant. The effects of 1.5% or 3.0% enflurane were quantitated by measuring contraction frequency and amplitude during an anesthetically steady state. The effects of prior anesthesia with 1.5% enflurane on uterine responses to 1.5 IU oxytocin i.v. were also evaluated. Neither 1.5% or 3.0% enflurane altered contraction amplitude or frequency in the 3 groups of rabbits. However, the amplitude of the contractile response to oxytocin 30 min following enflurane was significantly depressed. The results indicate that, while the intact rabbit uterus under different hormonal influences is not depressed by 1.5 or 3.0% enflurane, its response to oxytocin following enflurane is decreased.

Original languageEnglish (US)
Pages (from-to)160-165
Number of pages6
JournalAnesthesia and analgesia
Volume57
Issue number2
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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    Jones, D. J., Hodgson, B. J., Stehling, L. C., & Zauder, H. L. (1978). Enflurane and uterine contractility in rabbits. Anesthesia and analgesia, 57(2), 160-165. https://doi.org/10.1213/00000539-197803000-00002