Enflurane and uterine contractility in rabbits

D. J. Jones; B. J. Hodgson; L. C. Stehling; H. L. Zauder

doi:10.1213/00000539-197803000-00002

Enflurane and uterine contractility in rabbits

D. J. Jones, B. J. Hodgson, L. C. Stehling, H. L. Zauder

Anesthesiology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The effect of enflurane on uterine contractility was studied in sexually mature rabbits in which intrauterine balloon catheters had been implanted. Three animal groups were studied: untreated; treated with estrogen-progesterone; and 27-28 days pregnant. The effects of 1.5% or 3.0% enflurane were quantitated by measuring contraction frequency and amplitude during an anesthetically steady state. The effects of prior anesthesia with 1.5% enflurane on uterine responses to 1.5 IU oxytocin i.v. were also evaluated. Neither 1.5% or 3.0% enflurane altered contraction amplitude or frequency in the 3 groups of rabbits. However, the amplitude of the contractile response to oxytocin 30 min following enflurane was significantly depressed. The results indicate that, while the intact rabbit uterus under different hormonal influences is not depressed by 1.5 or 3.0% enflurane, its response to oxytocin following enflurane is decreased.

Original language	English (US)
Pages (from-to)	160-165
Number of pages	6
Journal	Anesthesia and analgesia
Volume	57
Issue number	2
DOIs	https://doi.org/10.1213/00000539-197803000-00002
State	Published - Jan 1 1978

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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title = "Enflurane and uterine contractility in rabbits",

abstract = "The effect of enflurane on uterine contractility was studied in sexually mature rabbits in which intrauterine balloon catheters had been implanted. Three animal groups were studied: untreated; treated with estrogen-progesterone; and 27-28 days pregnant. The effects of 1.5% or 3.0% enflurane were quantitated by measuring contraction frequency and amplitude during an anesthetically steady state. The effects of prior anesthesia with 1.5% enflurane on uterine responses to 1.5 IU oxytocin i.v. were also evaluated. Neither 1.5% or 3.0% enflurane altered contraction amplitude or frequency in the 3 groups of rabbits. However, the amplitude of the contractile response to oxytocin 30 min following enflurane was significantly depressed. The results indicate that, while the intact rabbit uterus under different hormonal influences is not depressed by 1.5 or 3.0% enflurane, its response to oxytocin following enflurane is decreased.",

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N2 - The effect of enflurane on uterine contractility was studied in sexually mature rabbits in which intrauterine balloon catheters had been implanted. Three animal groups were studied: untreated; treated with estrogen-progesterone; and 27-28 days pregnant. The effects of 1.5% or 3.0% enflurane were quantitated by measuring contraction frequency and amplitude during an anesthetically steady state. The effects of prior anesthesia with 1.5% enflurane on uterine responses to 1.5 IU oxytocin i.v. were also evaluated. Neither 1.5% or 3.0% enflurane altered contraction amplitude or frequency in the 3 groups of rabbits. However, the amplitude of the contractile response to oxytocin 30 min following enflurane was significantly depressed. The results indicate that, while the intact rabbit uterus under different hormonal influences is not depressed by 1.5 or 3.0% enflurane, its response to oxytocin following enflurane is decreased.

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