Endovascular treatment of intracranial aneurysms in Loeys - Dietz syndrome

Michael R. Levitt, Ryan P. Morton, Jeffrey C. Mai, Basavaraj Ghodke, Danial K. Hallam

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Background: Loeys - Dietz syndrome (LDS) is an autosomal dominant connective tissue disorder characterized by extensive arterial aneurysms. The successful clipping of intracranial aneurysms in patients with LDS has been reported in a limited number of patients but endovascular treatment of intracranial aneurysms in LDS has never before been described. The first successful cases of endovascular management of five intracranial aneurysms in two patients with LDS are reported. Clinical presentation: The first patient was an asymptomatic 45-year-old woman with LDS and two incidentally discovered, unruptured wide necked aneurysms (6X5 mm and 4X2 mm) arising from the ophthalmic segment of the left internal carotid artery. Both aneurysms were successfully embolized via Neuroform stent assisted coiling. The second patient was an asymptomatic middle 40s woman with LDS found to have an unruptured anterior communicating artery aneurysm (7X4 mm) as well as two ophthalmic segment aneurysms (2.5X3.7 mm and 2.9X3.5 mm). All three aneurysms were successfully embolized via Neuroform stent assisted coiling in two staged procedures. There were no periprocedural complications in either patient. Long term follow-up imaging demonstrated durable embolization in all aneurysms in both patients. Conclusion: This is the first reported case series of endovascular management of intracranial aneurysms in the setting of LDS. The endovascular approach was safe, effective and durable in all aneurysms in both patients, and should be considered when treating patients with LDS and intracranial aneurysms.

Original languageEnglish (US)
Pages (from-to)e37
JournalJournal of neurointerventional surgery
Volume4
Issue number6
DOIs
StatePublished - Nov 2012
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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