Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy

Roman A. Sukhovershin; Gautham Yepuri; Yohannes T. Ghebremariam

doi:10.14797/mdcj-11-3-166

Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy

Roman A. Sukhovershin, Gautham Yepuri, Yohannes T. Ghebremariam

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.

Original language	English (US)
Pages (from-to)	166-171
Number of pages	6
Journal	Methodist DeBakey cardiovascular journal
Volume	11
Issue number	3
DOIs	https://doi.org/10.14797/mdcj-11-3-166
State	Published - Jul 1 2015
Externally published	Yes

Keywords

antiatherogenic
asymmetric dimethylarginine
atherosclerosis
dimethylarginine dimethylaminohydrolase
endothelial nitric oxide synthase
endothelium
nitric oxide
vascular dysfunction

ASJC Scopus subject areas

General Medicine

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10.14797/mdcj-11-3-166

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abstract = "Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.",

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AB - Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.

KW - antiatherogenic

KW - asymmetric dimethylarginine

KW - atherosclerosis

KW - dimethylarginine dimethylaminohydrolase

KW - endothelial nitric oxide synthase

KW - endothelium

KW - nitric oxide

KW - vascular dysfunction

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Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy

Abstract

Keywords

ASJC Scopus subject areas

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