Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy

Roman A. Sukhovershin, Gautham Yepuri, Yohannes T. Ghebremariam

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.

Original languageEnglish (US)
Pages (from-to)166-171
Number of pages6
JournalMethodist DeBakey cardiovascular journal
Issue number3
StatePublished - Jul 1 2015
Externally publishedYes


  • antiatherogenic
  • asymmetric dimethylarginine
  • atherosclerosis
  • dimethylarginine dimethylaminohydrolase
  • endothelial nitric oxide synthase
  • endothelium
  • nitric oxide
  • vascular dysfunction

ASJC Scopus subject areas

  • General Medicine


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