Endothelin stimulates PDGF secretion in cultured human mesangial cells

Fatima E. Jaffer, Thomas C. Knauss, Earl Poptic, Hanna E. Abboud

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

Endothelin, a 17-DKa peptide originally described as a potent vasoconstrictor, also stimulates the release of important regulators of glomerular hemodynamics such as atrial natriuretic factor and renin. In the present study we investigated the role of endothelin in the release of another potent vasoconstrictor and mitogen of human mesangial cells, the platelet-derived growth factor. Endothelin stimulated PDGF release at 12 hours and the effect was sustained for 36 hours. This effect was associated with the enhanced induction of mRNAs encoding PDGF A-and B-chain. Endothelin also induced mitogenesis in human mesangial cells which was accompanied by activation of phospholipase C with increased inositol phosphate turnover. These data suggest a mechanism by which endothelin may regulate mesangial cell function in disease states.

Original languageEnglish (US)
Pages (from-to)1193-1198
Number of pages6
JournalKidney International
Volume38
Issue number6
DOIs
StatePublished - Dec 1990

ASJC Scopus subject areas

  • Nephrology

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