Endothelial chemokines in autoimmune disease

Kent W. Christopherson, Robert A. Hromas

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Compelling evidence now exists supporting the involvement of chemokines in the pathogenesis of autoimmune diseases. Examples of chemokines and chemokine receptors being involved in mediating autoimmune disease exist for rheumatoid arthritis, multiple sclerosis, allograft rejection, systemic lupus erythematosus, psoriasis, atopic dermatitis, lichen planus, and graft-versus-host-disease. Expression of chemokines by endothelial cells appears to be an important step in the development of these diseases. Since chemokines are small molecular weight molecules that act through G-protein coupled receptors, they make attractive drug targets. Several antagonists of chemokine - chemokine receptor interactions have been used to successfully alleviate some or all of the symptoms associated with many of these diseases in animal models. Further investigation of the involvement of chemokines in the pathogenesis or progression of autoimmune diseases may lead to practical clinical advances in diagnosis, prognosis, and therapy of such diseases.

Original languageEnglish (US)
Pages (from-to)145-154
Number of pages10
JournalCurrent pharmaceutical design
Volume10
Issue number2
DOIs
StatePublished - Jan 22 2004
Externally publishedYes

Keywords

  • Allograft rejection
  • Atopic dermatitis
  • Autoimmune disease
  • Chemokine
  • Chemokine receptor
  • Graft-virus-host-disease
  • Lichen planus
  • Multiple sclerosis
  • Psoriasis
  • Rheumatoid arthritis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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