Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis

Bravein Amalakuhan, Sheila A. Habib, Mandeep Mangat, Luis F. Reyes, Alejandro H. Rodriguez, Cecilia A. Hinojosa, Nilam J. Soni, Ryan P. Gilley, Carlos A. Bustamante, Antonio R Anzueto, Stephanie M Levine, Jay I Peters, Stefano Aliberti, Oriol Sibila, James D. Chalmers, Antoni Torres, Grant W. Waterer, Ignacio Martin-Loeches, Jose Bordon, Jose BlanquerFrancisco Sanz, Pedro J. Marcos, Jordi Rello, Julio Ramirez, Jordi Solé-Violán, Carlos M. Luna, Charles Feldman, Martin Witzenrath, Richard G. Wunderink, Daiana Stolz, Tim L. Wiemken, Yuichiro Shindo, Charles S. Dela Cruz, Carlos J. Orihuela, Marcos Restrepo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective To determine if serum levels of endothelial adhesion molecules were associated with the development of multiple organ failure (MOF) and in-hospital mortality in adult patients with severe sepsis. Design This study was a secondary data analysis of a prospective cohort study. Setting Patients were admitted to two tertiary intensive care units in San Antonio, TX, between 2007 and 2012. Patients Patients with severe sepsis at the time of intensive care unit (ICU) admission were enrolled. Inclusion criteria were consistent with previously published criteria for severe sepsis or septic shock in adults. Exclusion criteria included immunosuppressive medications or conditions. Interventions None. Measurements Baseline serum levels of the following endothelial cell adhesion molecules were measured within the first 72 h of ICU admission: Intracellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1), and Vascular Endothelial Growth Factor (VEGF). The primary and secondary outcomes were development of MOF (⩾2 organ dysfunction) and in-hospital mortality, respectively. Main results Forty-eight patients were enrolled in this study, of which 29 (60%) developed MOF. Patients that developed MOF had higher levels of VCAM-1 (p = 0.01) and ICAM-1 (p = 0.01), but not VEGF (p = 0.70) compared with patients without MOF (single organ failure only). The area under the curve (AUC) to predict MOF according to VCAM-1, ICAM-1 and VEGF was 0.71, 0.73, and 0.54, respectively. Only increased VCAM-1 levels were associated with in-hospital mortality (p = 0.03). These associations were maintained even after adjusting for APACHE and SOFA scores using logistic regression. Conclusions High levels of serum ICAM-1 was associated with the development of MOF. High levels of VCAM-1 was associated with both MOF and in-hospital mortality.

Original languageEnglish (US)
Pages (from-to)267-273
Number of pages7
JournalCytokine
Volume88
DOIs
StatePublished - Dec 1 2016

Fingerprint

Multiple Organ Failure
Vascular Cell Adhesion Molecule-1
Sepsis
Adhesion
Intensive care units
Molecules
Vascular Endothelial Growth Factor A
Hospital Mortality
Intensive Care Units
Endothelial cells
Cell Adhesion Molecules
Immunosuppressive Agents
Serum
Logistics
APACHE
Tertiary Healthcare
Septic Shock
Area Under Curve
Cohort Studies
Endothelial Cells

Keywords

  • Biomarkers
  • Intracellular Adhesion Molecule-1
  • Mortality
  • Multiple organ failure
  • Sepsis
  • Shock
  • Vascular Cell Adhesion Molecule-1
  • Vascular Endothelial Growth Factor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

Cite this

Amalakuhan, B., Habib, S. A., Mangat, M., Reyes, L. F., Rodriguez, A. H., Hinojosa, C. A., ... Restrepo, M. (2016). Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis. Cytokine, 88, 267-273. https://doi.org/10.1016/j.cyto.2016.08.028

Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis. / Amalakuhan, Bravein; Habib, Sheila A.; Mangat, Mandeep; Reyes, Luis F.; Rodriguez, Alejandro H.; Hinojosa, Cecilia A.; Soni, Nilam J.; Gilley, Ryan P.; Bustamante, Carlos A.; Anzueto, Antonio R; Levine, Stephanie M; Peters, Jay I; Aliberti, Stefano; Sibila, Oriol; Chalmers, James D.; Torres, Antoni; Waterer, Grant W.; Martin-Loeches, Ignacio; Bordon, Jose; Blanquer, Jose; Sanz, Francisco; Marcos, Pedro J.; Rello, Jordi; Ramirez, Julio; Solé-Violán, Jordi; Luna, Carlos M.; Feldman, Charles; Witzenrath, Martin; Wunderink, Richard G.; Stolz, Daiana; Wiemken, Tim L.; Shindo, Yuichiro; Dela Cruz, Charles S.; Orihuela, Carlos J.; Restrepo, Marcos.

In: Cytokine, Vol. 88, 01.12.2016, p. 267-273.

Research output: Contribution to journalArticle

Amalakuhan, B, Habib, SA, Mangat, M, Reyes, LF, Rodriguez, AH, Hinojosa, CA, Soni, NJ, Gilley, RP, Bustamante, CA, Anzueto, AR, Levine, SM, Peters, JI, Aliberti, S, Sibila, O, Chalmers, JD, Torres, A, Waterer, GW, Martin-Loeches, I, Bordon, J, Blanquer, J, Sanz, F, Marcos, PJ, Rello, J, Ramirez, J, Solé-Violán, J, Luna, CM, Feldman, C, Witzenrath, M, Wunderink, RG, Stolz, D, Wiemken, TL, Shindo, Y, Dela Cruz, CS, Orihuela, CJ & Restrepo, M 2016, 'Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis', Cytokine, vol. 88, pp. 267-273. https://doi.org/10.1016/j.cyto.2016.08.028
Amalakuhan B, Habib SA, Mangat M, Reyes LF, Rodriguez AH, Hinojosa CA et al. Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis. Cytokine. 2016 Dec 1;88:267-273. https://doi.org/10.1016/j.cyto.2016.08.028
Amalakuhan, Bravein ; Habib, Sheila A. ; Mangat, Mandeep ; Reyes, Luis F. ; Rodriguez, Alejandro H. ; Hinojosa, Cecilia A. ; Soni, Nilam J. ; Gilley, Ryan P. ; Bustamante, Carlos A. ; Anzueto, Antonio R ; Levine, Stephanie M ; Peters, Jay I ; Aliberti, Stefano ; Sibila, Oriol ; Chalmers, James D. ; Torres, Antoni ; Waterer, Grant W. ; Martin-Loeches, Ignacio ; Bordon, Jose ; Blanquer, Jose ; Sanz, Francisco ; Marcos, Pedro J. ; Rello, Jordi ; Ramirez, Julio ; Solé-Violán, Jordi ; Luna, Carlos M. ; Feldman, Charles ; Witzenrath, Martin ; Wunderink, Richard G. ; Stolz, Daiana ; Wiemken, Tim L. ; Shindo, Yuichiro ; Dela Cruz, Charles S. ; Orihuela, Carlos J. ; Restrepo, Marcos. / Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis. In: Cytokine. 2016 ; Vol. 88. pp. 267-273.
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abstract = "Objective To determine if serum levels of endothelial adhesion molecules were associated with the development of multiple organ failure (MOF) and in-hospital mortality in adult patients with severe sepsis. Design This study was a secondary data analysis of a prospective cohort study. Setting Patients were admitted to two tertiary intensive care units in San Antonio, TX, between 2007 and 2012. Patients Patients with severe sepsis at the time of intensive care unit (ICU) admission were enrolled. Inclusion criteria were consistent with previously published criteria for severe sepsis or septic shock in adults. Exclusion criteria included immunosuppressive medications or conditions. Interventions None. Measurements Baseline serum levels of the following endothelial cell adhesion molecules were measured within the first 72 h of ICU admission: Intracellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1), and Vascular Endothelial Growth Factor (VEGF). The primary and secondary outcomes were development of MOF (⩾2 organ dysfunction) and in-hospital mortality, respectively. Main results Forty-eight patients were enrolled in this study, of which 29 (60{\%}) developed MOF. Patients that developed MOF had higher levels of VCAM-1 (p = 0.01) and ICAM-1 (p = 0.01), but not VEGF (p = 0.70) compared with patients without MOF (single organ failure only). The area under the curve (AUC) to predict MOF according to VCAM-1, ICAM-1 and VEGF was 0.71, 0.73, and 0.54, respectively. Only increased VCAM-1 levels were associated with in-hospital mortality (p = 0.03). These associations were maintained even after adjusting for APACHE and SOFA scores using logistic regression. Conclusions High levels of serum ICAM-1 was associated with the development of MOF. High levels of VCAM-1 was associated with both MOF and in-hospital mortality.",
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TY - JOUR

T1 - Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis

AU - Amalakuhan, Bravein

AU - Habib, Sheila A.

AU - Mangat, Mandeep

AU - Reyes, Luis F.

AU - Rodriguez, Alejandro H.

AU - Hinojosa, Cecilia A.

AU - Soni, Nilam J.

AU - Gilley, Ryan P.

AU - Bustamante, Carlos A.

AU - Anzueto, Antonio R

AU - Levine, Stephanie M

AU - Peters, Jay I

AU - Aliberti, Stefano

AU - Sibila, Oriol

AU - Chalmers, James D.

AU - Torres, Antoni

AU - Waterer, Grant W.

AU - Martin-Loeches, Ignacio

AU - Bordon, Jose

AU - Blanquer, Jose

AU - Sanz, Francisco

AU - Marcos, Pedro J.

AU - Rello, Jordi

AU - Ramirez, Julio

AU - Solé-Violán, Jordi

AU - Luna, Carlos M.

AU - Feldman, Charles

AU - Witzenrath, Martin

AU - Wunderink, Richard G.

AU - Stolz, Daiana

AU - Wiemken, Tim L.

AU - Shindo, Yuichiro

AU - Dela Cruz, Charles S.

AU - Orihuela, Carlos J.

AU - Restrepo, Marcos

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Objective To determine if serum levels of endothelial adhesion molecules were associated with the development of multiple organ failure (MOF) and in-hospital mortality in adult patients with severe sepsis. Design This study was a secondary data analysis of a prospective cohort study. Setting Patients were admitted to two tertiary intensive care units in San Antonio, TX, between 2007 and 2012. Patients Patients with severe sepsis at the time of intensive care unit (ICU) admission were enrolled. Inclusion criteria were consistent with previously published criteria for severe sepsis or septic shock in adults. Exclusion criteria included immunosuppressive medications or conditions. Interventions None. Measurements Baseline serum levels of the following endothelial cell adhesion molecules were measured within the first 72 h of ICU admission: Intracellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1), and Vascular Endothelial Growth Factor (VEGF). The primary and secondary outcomes were development of MOF (⩾2 organ dysfunction) and in-hospital mortality, respectively. Main results Forty-eight patients were enrolled in this study, of which 29 (60%) developed MOF. Patients that developed MOF had higher levels of VCAM-1 (p = 0.01) and ICAM-1 (p = 0.01), but not VEGF (p = 0.70) compared with patients without MOF (single organ failure only). The area under the curve (AUC) to predict MOF according to VCAM-1, ICAM-1 and VEGF was 0.71, 0.73, and 0.54, respectively. Only increased VCAM-1 levels were associated with in-hospital mortality (p = 0.03). These associations were maintained even after adjusting for APACHE and SOFA scores using logistic regression. Conclusions High levels of serum ICAM-1 was associated with the development of MOF. High levels of VCAM-1 was associated with both MOF and in-hospital mortality.

AB - Objective To determine if serum levels of endothelial adhesion molecules were associated with the development of multiple organ failure (MOF) and in-hospital mortality in adult patients with severe sepsis. Design This study was a secondary data analysis of a prospective cohort study. Setting Patients were admitted to two tertiary intensive care units in San Antonio, TX, between 2007 and 2012. Patients Patients with severe sepsis at the time of intensive care unit (ICU) admission were enrolled. Inclusion criteria were consistent with previously published criteria for severe sepsis or septic shock in adults. Exclusion criteria included immunosuppressive medications or conditions. Interventions None. Measurements Baseline serum levels of the following endothelial cell adhesion molecules were measured within the first 72 h of ICU admission: Intracellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1), and Vascular Endothelial Growth Factor (VEGF). The primary and secondary outcomes were development of MOF (⩾2 organ dysfunction) and in-hospital mortality, respectively. Main results Forty-eight patients were enrolled in this study, of which 29 (60%) developed MOF. Patients that developed MOF had higher levels of VCAM-1 (p = 0.01) and ICAM-1 (p = 0.01), but not VEGF (p = 0.70) compared with patients without MOF (single organ failure only). The area under the curve (AUC) to predict MOF according to VCAM-1, ICAM-1 and VEGF was 0.71, 0.73, and 0.54, respectively. Only increased VCAM-1 levels were associated with in-hospital mortality (p = 0.03). These associations were maintained even after adjusting for APACHE and SOFA scores using logistic regression. Conclusions High levels of serum ICAM-1 was associated with the development of MOF. High levels of VCAM-1 was associated with both MOF and in-hospital mortality.

KW - Biomarkers

KW - Intracellular Adhesion Molecule-1

KW - Mortality

KW - Multiple organ failure

KW - Sepsis

KW - Shock

KW - Vascular Cell Adhesion Molecule-1

KW - Vascular Endothelial Growth Factor

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U2 - 10.1016/j.cyto.2016.08.028

DO - 10.1016/j.cyto.2016.08.028

M3 - Article

C2 - 27701021

AN - SCOPUS:84988931080

VL - 88

SP - 267

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JO - Cytokine

JF - Cytokine

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