Endometrial and cervical polyps in 22 baboons (Papio sp.), 5 cynomolgus macaques (Macaca fascicularis) and one marmoset (Callithrix jacchus)

Melissa W. Bennett, Edward J. Dick, Natalia E. Schlabritz-Loutsevitch, Juan C. Lopez-Alvarenga, Priscilla C. Williams, R. Mark Sharp, Gene B. Hubbard

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background: Endometrial and cervical polyps are masses of endometrium or cervical epithelium that bulge into the uterine or cervical lumen. The physiopathology and contributing factors of endometrial polyps development are still unknown. Methods: Clinical and pathology records of 28 non-human primates with histologically confirmed endometrial and cervical polyps were reviewed. Twenty-one baboons with endometrial polyps were evaluated for age at diagnosis, body weight, menstrual cycle length, presence of endometriosis and adenomyosis and number of offspring, cesarean sections, and stillbirths. Results: Endometrial polyps in baboons were associated with increased age, decreased menstrual cycle lengths, endometriosis, and decreased parity. No differences were found for weight, adenomyosis, or number of cesarean sections or stillbirths. Conclusions: Baboons are a promising model for the study of endometrial polyps because of their similarity to humans in both the development of endometrial polyps and association of many of the same risk factors.

Original languageEnglish (US)
Pages (from-to)257-262
Number of pages6
JournalJournal of medical primatology
Volume38
Issue number4
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Cancer
  • Endometrium
  • Mass
  • Non-human
  • Primate
  • Uterus

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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