TY - JOUR
T1 - Endometrial and cervical polyps in 22 baboons (Papio sp.), 5 cynomolgus macaques (Macaca fascicularis) and one marmoset (Callithrix jacchus)
AU - Bennett, Melissa W.
AU - Dick, Edward J.
AU - Schlabritz-Loutsevitch, Natalia E.
AU - Lopez-Alvarenga, Juan C.
AU - Williams, Priscilla C.
AU - Sharp, R. Mark
AU - Hubbard, Gene B.
PY - 2009
Y1 - 2009
N2 - Background: Endometrial and cervical polyps are masses of endometrium or cervical epithelium that bulge into the uterine or cervical lumen. The physiopathology and contributing factors of endometrial polyps development are still unknown. Methods: Clinical and pathology records of 28 non-human primates with histologically confirmed endometrial and cervical polyps were reviewed. Twenty-one baboons with endometrial polyps were evaluated for age at diagnosis, body weight, menstrual cycle length, presence of endometriosis and adenomyosis and number of offspring, cesarean sections, and stillbirths. Results: Endometrial polyps in baboons were associated with increased age, decreased menstrual cycle lengths, endometriosis, and decreased parity. No differences were found for weight, adenomyosis, or number of cesarean sections or stillbirths. Conclusions: Baboons are a promising model for the study of endometrial polyps because of their similarity to humans in both the development of endometrial polyps and association of many of the same risk factors.
AB - Background: Endometrial and cervical polyps are masses of endometrium or cervical epithelium that bulge into the uterine or cervical lumen. The physiopathology and contributing factors of endometrial polyps development are still unknown. Methods: Clinical and pathology records of 28 non-human primates with histologically confirmed endometrial and cervical polyps were reviewed. Twenty-one baboons with endometrial polyps were evaluated for age at diagnosis, body weight, menstrual cycle length, presence of endometriosis and adenomyosis and number of offspring, cesarean sections, and stillbirths. Results: Endometrial polyps in baboons were associated with increased age, decreased menstrual cycle lengths, endometriosis, and decreased parity. No differences were found for weight, adenomyosis, or number of cesarean sections or stillbirths. Conclusions: Baboons are a promising model for the study of endometrial polyps because of their similarity to humans in both the development of endometrial polyps and association of many of the same risk factors.
KW - Cancer
KW - Endometrium
KW - Mass
KW - Non-human
KW - Primate
KW - Uterus
UR - http://www.scopus.com/inward/record.url?scp=67650480429&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650480429&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0684.2009.00350.x
DO - 10.1111/j.1600-0684.2009.00350.x
M3 - Article
C2 - 19281481
AN - SCOPUS:67650480429
VL - 38
SP - 257
EP - 262
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
IS - 4
ER -