Abstract
A rabbit model of endolymphatic hydrops was studied using detailed functional and cytohistologic methods. Immediately following surgical destruction of the endolymphatic sac and the distal portion of the duct, measures of the evoked auditory brainstem response (ABR) revealed mild to profound losses specific to low- and high-frequency test stimuli while responses to mid-frequency signals remained unchanged for the majority of animals. Rabbits exhibited varying degrees of vestibular upset involving both overt behavior and reduced responses to caloric stimulation. Histologic processing of the plastic embedded cochleae demonstrated distended Reissner's membranes along with extensive damage to apical and basal turn sensory cells and myelinated afferent nerve fibers while the middle portion of the cochlear duct remained relatively unaltered. An atypical pattern of hair cell lesions involving a greater loss for inner than for outer hair cells was identified at the interface between damaged apical sensorineural elements and the normal appearing organ of Corti of the middle turns.
Original language | English (US) |
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Pages (from-to) | 65-87 |
Number of pages | 23 |
Journal | Hearing Research |
Volume | 12 |
Issue number | 1 |
DOIs | |
State | Published - Oct 1983 |
Keywords
- auditory brainstem response
- cochlear hair cell loss
- endolymphatic hydrops
ASJC Scopus subject areas
- Sensory Systems