Endogenous endophthalmitis: A 10-year retrospective study at a tertiary hospital in South India

Dhanashree Ratra, Kumar Saurabh, Debmalya Das, Kasinathan Nachiappan, Amit Nagpal, Ekta Rishi, Pramod Bhende, Tarun Sharma, Lingam Gopal

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Purpose: The aim of this study was to review the clinical profile including predisposing systemic conditions, microorganisms responsible, clinical presentation, and outcomes of endogenous endophthalmitis (EE) in South India. Design: This study is a retrospective, noncomparative case series. Methods: This study presents a retrospective analysis of records of patients with EE in a 10-year period. Results: A total of 61 eyes of 58 patients were included in the study. Preceding systemic illness or surgery was noted in 31 patients (53.4%). No predisposing condition was found in 27 patients (46.5%). All eyes had severe diffuse EE. Culture positivity was seen in 34 of 58 patients (58.6%). Gram-positive organisms were isolated in 9 cases (15.5%), and Gram-negative organisms were isolated in 20 cases (34.5%). Pseudomonas aeruginosa (13.8%) was the most common isolate. Eleven eyes (18%) were managed medically with intravenous and intravitreal antibiotics, and 38 eyes (62.3%) also underwent vitrectomy. Eight eyes (13.1%) required repeat vitrectomy, and 12 eyes (19.7%) were eviscerated. The mean follow-up was 16.2 ± 13.9 months. Final visual acuity of 20/200 or better was seen in 29.5% eyes. A favorable outcome was noted in culture-positive patients (P = 0.03) and in patients with no predisposing causes. Conclusions: This study provides information about the clinical and microbiologic profile of EE. Aggressive medical and surgical treatment can result in favorable outcomes.

Original languageEnglish (US)
Pages (from-to)286-292
Number of pages7
JournalAsia-Pacific Journal of Ophthalmology
Issue number5
StatePublished - 2015
Externally publishedYes


  • Adult
  • Diabetes mellitus
  • Endogenous endophthalmitis
  • India
  • Pseudomonas
  • Vitrectomy

ASJC Scopus subject areas

  • Ophthalmology


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