Endogenous cannabinoid signaling and psychomotor disorders

A. Giuffrida, F. Désarnaud, D. Piomelli

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The effects of cannabinoids on motor behaviors and cognitive functions are well documented. The discovery of the CB1 cannabinoid receptor and the mapping of its distribution in the central nervous system have provided a rationale to elucidate the molecular and cellular mechanisms of cannabinoid actions. The identification of naturally occurring ligands for these receptors, anandamide and 2-arachidonylglycerol, has prompted a large research effort aimed at investigating the physiological role of the endogenous cannabinoid system, as well as its potential use as a target for novel therapeutic interventions. This mini-review discusses the participation of the endogenous cannabinoid system in the regulation of motor behaviors, pointing out its possible involvement in the pathophysiology of psychomotor disorders. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)63-70
Number of pages8
JournalProstaglandins and Other Lipid Mediators
Issue number1-2
StatePublished - Apr 2000
Externally publishedYes


  • 2-Arachidonylglycerol
  • Anandamide
  • Basal ganglia
  • Cannabinoid receptors
  • Motor disorders

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology


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