Endocytic control of growth factor signalling: Multivesicular bodies as signalling organelles

Radek Dobrowolski, Edward M. De Robertis

Research output: Contribution to journalReview articlepeer-review

111 Scopus citations

Abstract

Signal transduction and endocytosis are intertwined processes. The internalization of ligand-activated receptors by endocytosis has classically been thought to attenuate signals by targeting receptors for degradation in lysosomes, but it can also maintain signals in early signalling endosomes. In both cases, localization to multivesicular endosomesen route to lysosomes is thought to terminate signalling. However, during WNT signal transduction, sequestration of the enzyme glycogen synthase kinase 3 (GSK3) inside multivesicular endosomes results in the stabilization of many cytosolic proteins. Thus, the role of endocytosis during signal transduction may be more diverse than anticipated, and multivesicular endosomes may constitute a crucial signalling organelle.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalNature Reviews Molecular Cell Biology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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