Endocrine therapy for leptomeningeal metastases from ER-Positive breast cancer: Case report and a review of the literature

Behyar Zoghi, Richard Elledge

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Leptomeningeal disease is an uncommon complication of estrogen receptor positive breast cancer. While there is little consensus on the standard of care, recommendations from current clinical practice guidelines are to treat with intrathecal chemotherapy, necessitating invasive procedures and potentially resulting in a substantial incidence of serious complications and side effects. Here, we review all published evidence of the effectiveness of systemic hormonal therapy alone in treating this condition, with the advantage of requiring no invasive procedures and having virtually no serious complications or side effects. Evidence indicates that most hormonal therapies can penetrate the central nervous system and can be an effective treatment of endocrine sensitive breast cancer that is widely metastatic to the leptomeninges.

Original languageEnglish (US)
Pages (from-to)218-223
Number of pages6
JournalBreast Journal
Volume22
Issue number2
DOIs
StatePublished - Mar 1 2016

Keywords

  • Breast cancer
  • ER-positive
  • Endocrine therapy
  • Leptomeningeal

ASJC Scopus subject areas

  • Internal Medicine
  • Surgery
  • Oncology

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