TY - JOUR
T1 - Endocrine changes during 48 hours of food withdrawal in the pregnant rhesus monkey in the last third of gestation
AU - Binienda, Z.
AU - Massmann, A.
AU - Wimsatt, J.
AU - Honnebier, M. B.O.M.
AU - Figueroa, J. P.
AU - Reimers, T. J.
AU - Nathanielsz, P. W.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1989/6
Y1 - 1989/6
N2 - We studied the hormonal responses in four pregnant rhesus monkeys between 112 and 149 days gestation. After 2 days, during which the monkeys were fed ad libitum, their food was withdrawn at 1500 h for 48 h while allowing free access to water. The food then was returned, and the animals were studied for a further 2 days. The mean maternal whole blood glucose concentration significantly decreased, and plasma cortisol and dehydroepiandrosterone sulfate (DHEAS) concentrations significantly increased within 30 h of food withdrawal (P < 0.05). The maternal plasma estradiol concentration increased significantly at 1000 h on the second day of food withdrawal (P < 0.05), whereas the plasma progesterone concentration did not change. The maternal blood glucose and plasma cortisol, DHEAS and estradiol concentrations returned to baseline by the second day of food replacement. We conclude that the stress of hypoglycemia and/or the attendant inability to eat, together or separately, stimulate maternal adrenal glucocorticoid and androgen secretion during the period of food withdrawal. The increased maternal DHEAS and perhaps other adrenal androgen concentrations result in increased maternal estrogen production.
AB - We studied the hormonal responses in four pregnant rhesus monkeys between 112 and 149 days gestation. After 2 days, during which the monkeys were fed ad libitum, their food was withdrawn at 1500 h for 48 h while allowing free access to water. The food then was returned, and the animals were studied for a further 2 days. The mean maternal whole blood glucose concentration significantly decreased, and plasma cortisol and dehydroepiandrosterone sulfate (DHEAS) concentrations significantly increased within 30 h of food withdrawal (P < 0.05). The maternal plasma estradiol concentration increased significantly at 1000 h on the second day of food withdrawal (P < 0.05), whereas the plasma progesterone concentration did not change. The maternal blood glucose and plasma cortisol, DHEAS and estradiol concentrations returned to baseline by the second day of food replacement. We conclude that the stress of hypoglycemia and/or the attendant inability to eat, together or separately, stimulate maternal adrenal glucocorticoid and androgen secretion during the period of food withdrawal. The increased maternal DHEAS and perhaps other adrenal androgen concentrations result in increased maternal estrogen production.
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U2 - 10.1210/jcem-68-6-1184
DO - 10.1210/jcem-68-6-1184
M3 - Article
C2 - 2524502
AN - SCOPUS:0024381046
VL - 68
SP - 1184
EP - 1188
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 6
ER -