Endocervical neoplasia in long-term users of oral contraceptives: Clinical and pathologic observations

Philip T Valente, P. Hanjani

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Adenocarcinoma of the cervix has been associated with oral contraceptive use, often prolonged. The clinicopathologic features of seven cases of endocervical neoplasia in long-term combination pill users, all 33 years of age or younger, were reviewed and compared with seven cases in nonusers. Duration of drug use ranged from 4.5 to nine years. Adenocarcinoma in situ was found in all cases either in pure form or associated in invasive adeno- or adenosquamous carcinoma; squamous carcinoma in situ (CIS) was seen in two cases, one of which showed focal microinvasion. Hypersecretory changes were seen in adjacent endocervix in two cases but the morphology of neoplastic lesions was similar to that unassociated with pill use. The possible role of chronic hormonal stimulation in cervical carcinogenesis is discussed in light of these findings and current epidemiologic data.

Original languageEnglish (US)
Pages (from-to)695-704
Number of pages10
JournalObstetrics and Gynecology
Volume67
Issue number5
StatePublished - 1986
Externally publishedYes

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Adenosquamous Carcinoma
Carcinoma in Situ
Oral Contraceptives
Cervix Uteri
Squamous Cell Carcinoma
Carcinogenesis
Adenocarcinoma
Pharmaceutical Preparations
Neoplasms
Adenocarcinoma in Situ

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Endocervical neoplasia in long-term users of oral contraceptives : Clinical and pathologic observations. / Valente, Philip T; Hanjani, P.

In: Obstetrics and Gynecology, Vol. 67, No. 5, 1986, p. 695-704.

Research output: Contribution to journalArticle

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