Endocervical neoplasia in long-term users of oral contraceptives: Clinical and pathologic observations

Philip T. Valente, P. Hanjani

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Adenocarcinoma of the cervix has been associated with oral contraceptive use, often prolonged. The clinicopathologic features of seven cases of endocervical neoplasia in longterm combination pill users, all 33 years of age or younger, were reviewed and compared with seven cases in nonusers. Duration of drug use ranged from 4.5 to nine years. Adenocarcinoma in situ was found in all cases either in pure form or associated in invasive adeno- or adenosquamous carcinoma; squamous carcinoma in situ (CIS) was seen in two cases, one of which showed focal microinvasion. Hypersecretory changes were seen in adjacent endocervix in two cases but the morphology of neoplastic lesions was similar to that unassociated with pill use. The possible role of chronic hormonal stimulation in cervical carcinogenesis is discussed in light of these findings and current epidemiologic data.

Original languageEnglish (US)
Pages (from-to)695-704
Number of pages10
JournalObstetrics and Gynecology
Volume67
Issue number5
DOIs
StatePublished - May 1986
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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