Empirical evidence that the state dependence and drug discrimination paradigms can generate different outcomes

F. C. Colpaert, W. Koek

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The study compared the outcomes generated by the State Dependence and Drug Discrimination paradigms with ethanol in the rat. Food-deprived rats learned to complete a fixed-ratio 10 schedule of bar presses for food within 120 s while treated with 320- to 1250-mg/kg doses of ethanol. Subsequent tests of recall of this response with saline failed to generate any evidence that transfer was hampered following the drug-to-saline state change. In contrast, each of 14 rats learned to discriminate 1250 mg/kg ethanol from saline in a Drug Discrimination procedure that also required the animals to press one of two levers for food according to a fixed- ratio 10 schedule. The results offer the first empirical evidence to demonstrate directly that the State Dependence and Drug Discrimination paradigms can generate different outcomes in otherwise identical experimental conditions.

Original languageEnglish (US)
Pages (from-to)272-279
Number of pages8
JournalPsychopharmacology
Volume120
Issue number3
DOIs
StatePublished - Aug 1 1995
Externally publishedYes

Keywords

  • Cue
  • Drug discrimination
  • Ethanol
  • Learning
  • Memory
  • State
  • State dependence

ASJC Scopus subject areas

  • Pharmacology

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