Emphysema quantification in inflation-fixed lungs using low-dose computed tomography and 3he magnetic resonance imaging

David S. Gierada, Jason C. Woods, Richard E. Jacob, Andrew J. Bierhals, Cliff K. Choong, Seth T. Bartel, Yulin V. Chang, Nitin A. Das, Cheng Hong, Barbara A. Lutey, Jon H. Ritter, Thomas K. Pilgram, Joel D. Cooper, G. Alexander Patterson, Richard J. Battafarano, Bryan F. Meyers, Dmitriy A. Yablonskiy, Mark S. Conradi

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objective: To evaluate the use of inflation-fixed lung tissue for emphysema quantification with computed tomography (CT) and 3He magnetic resonance (MR) diffusion imaging. Methods: Fourteen subjects representing a range of chronic obstructive pulmonary disease severity who underwent complete or lobar lung resection were studied. Computed tomographic measurements of lung attenuation and MR measurements of the hyperpolarized 3He apparent diffusion coefficient (ADC) in resected specimens fixed in inflation with heated formalin vapor were compared with measurements obtained before fixation. Results: The mean (SD) CT emphysema indices were 56% (17%) before and 58% (19%) after fixation (P = 0.77; R = 0.76). Index differences correlated with differences in lung volume (R 2 = 0.47). The mean (SD) 3He ADCs were 0.40 (0.15) cm 2/s before and 0.39 (0.14) cm2/s after fixation (P = 0.03, R = 0.98). The CT emphysema index and the 3He ADC were correlated before (R = 0.89) and after fixation (R = 0.79). Conclusions: Concordance of CTand 3He MR imaging measurements in unfixed and inflation-fixed lungs supports the use of inflation-fixed lungs for quantitative imaging studies in emphysema.

Original languageEnglish (US)
Pages (from-to)773-779
Number of pages7
JournalJournal of Computer Assisted Tomography
Issue number5
StatePublished - Sep 2010
Externally publishedYes


  • CT
  • Emphysema
  • MR
  • Quantitative imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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