Emerging significance of estrogen receptor coregulator signaling in breast cancer

M. Mann, S. Krishnan, R. K. Vadlamudi

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Estrogen receptor (ERα) plays an important role in the initiation and progression of breast cancer. Many breast cancer patients respond positively to hormonal therapy; however, initial or acquired resistance to endocrine therapies frequently occurs and tumors recur as metastases. Emerging evidence suggests that ERα action is complex and involves functional interactions with coregulators. The levels of ERα coregulator proteins are tightly regulated under normal conditions and ERα-coregulator proteins have the potential to be differentially expressed in malignant tumors and have altered functions leading to tumor progression and metastases. In this review, we summarize recent findings that relate to ERα coregulators and discuss implications of ERα coregulator deregulation in breast cancer metastasis.

Original languageEnglish (US)
Pages (from-to)75-88
Number of pages14
JournalMinerva Ginecologica
Volume64
Issue number1
Publication statusPublished - Feb 1 2012

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Keywords

  • Breast neoplasms
  • Estrogens
  • Hormones
  • Receptors, estrogen

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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