Emerging significance of ER-coregulator PELP1/MNAR in cancer

S. Nair, Ratna K. Vadlamudi

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

The estrogen receptors ERα and ERβ have been implicated in the progression of a wide variety of cancers. The actions of ER are regulated by ER coregulator proteins, including proline-, glutamic acid-and leucine-rich-protein-1 (PELP1/MNAR). PELP1 has been shown to participate in both genomic and nongenomic functions of ER. The expression and localization of PELP1/MNAR are deregulated in a wide variety of tumors and have been implicated in the development of hormonal resistance in cancer cell lines. Emerging data suggest that PELP1/MNAR interacts with many proteins and activates several oncogenes, including Src kinase, phosphotidyl inositol 3 kinase (PI3K), and signal transducers and activators of transcription 3 (STAT3). These new results suggest that PELP1/MNAR may act as an oncogene as well as cooperating with other oncogenes. Thus, PELP1/MNAR may contribute to the tumorigenic potential of cancer cells by serving as a scaffolding protein that couples various signaling complexes with ER.

Original languageEnglish (US)
Pages (from-to)91-96
Number of pages6
JournalHistology and Histopathology
Volume22
Issue number1-3
StatePublished - Jan 2007

Keywords

  • Coregulators
  • Estrogen receptors
  • Hormonal resistance
  • MNAR
  • PELP1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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