Emerging role of transplantation for primary liver cancers

Nicholas N. Nissen, Emanuel Cavazzoni, Tram T. Tran, Fred P. Poordad

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Liver transplantation (LT) has been utilized in the treatment of primary hepatic malignancy for decades. Hepatocellular cancer (HCC) remains the most common malignant condition treated with LT, with almost 400 such transplants performed annually in the US. Refinement in the selection criteria for LT in patients with HCC has led to survival rates similar to those for LT in nonmalignant conditions. Excellent results have also been reported following LT for select patients with epithelioid hemangioendothelioma and hepatoblastoma. Patients with cholangiocarcinoma treated with LT have generally faired poorly, with survival rates far below that of LT for nonmalignant conditions. Improved survival has recently been reported following LT for cholangiocarcinoma in highly select patients treated with aggressive neoadjuvant therapy. The future utility of LT in the treatment of malignancy will be influenced by several factors, including a profound organ donor shortage faced worldwide; increasing prevalence of hepatitis C, HCC and cirrhosis; and the evolution of live donor liver transplantation.

Original languageEnglish (US)
Pages (from-to)88-96
Number of pages9
JournalCancer Journal
Volume10
Issue number2
DOIs
StatePublished - Mar 1 2004
Externally publishedYes

Keywords

  • Hepatecellular cancer
  • Liver transplantation
  • MELD
  • Primary hepatic cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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