TY - JOUR
T1 - Emerging aspects of nanotoxicology in health and disease
T2 - From agriculture and food sector to cancer therapeutics
AU - Piperigkou, Zoi
AU - Karamanou, Konstantina
AU - Engin, Ayse Basak
AU - Gialeli, Chrysostomi
AU - Docea, Anca Oana
AU - Vynios, Demitrios H.
AU - Pavão, Mauro S.G.
AU - Golokhvast, Kirill S.
AU - Shtilman, Mikhail I.
AU - Argiris, Athanassios
AU - Shishatskaya, Ekaterina
AU - Tsatsakis, Aristidis M.
N1 - Funding Information:
This study was supported by the Russian Scientific Foundation ( 15-14-20032 ), which involved participation of A. Tsatsakis and K. Golokhvast).
Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Nanotechnology is an evolving scientific field that has allowed the manufacturing of materials with novel physicochemical and biological properties, offering a wide spectrum of potential applications. Properties of nanoparticles that contribute to their usefulness include their markedly increased surface area in relation to mass, surface reactivity and insolubility, ability to agglomerate or change size in different media and enhanced endurance over conventional-scale substance. Here, we review nanoparticle classification and their emerging applications in several fields; from active food packaging to drug delivery and cancer research. Nanotechnology has exciting therapeutic applications, including novel drug delivery for the treatment of cancer. Additionally, we discuss that exposure to nanostructures incorporated to polymer composites, may result in potential human health risks. Therefore, the knowledge of processes, including absorption, distribution, metabolism and excretion, as well as careful toxicological assessment is critical in order to determine the effects of nanomaterials in humans and other biological systems. Expanding the knowledge of nanoparticle toxicity will facilitate designing of safer nanocomposites and their application in a beneficial manner.
AB - Nanotechnology is an evolving scientific field that has allowed the manufacturing of materials with novel physicochemical and biological properties, offering a wide spectrum of potential applications. Properties of nanoparticles that contribute to their usefulness include their markedly increased surface area in relation to mass, surface reactivity and insolubility, ability to agglomerate or change size in different media and enhanced endurance over conventional-scale substance. Here, we review nanoparticle classification and their emerging applications in several fields; from active food packaging to drug delivery and cancer research. Nanotechnology has exciting therapeutic applications, including novel drug delivery for the treatment of cancer. Additionally, we discuss that exposure to nanostructures incorporated to polymer composites, may result in potential human health risks. Therefore, the knowledge of processes, including absorption, distribution, metabolism and excretion, as well as careful toxicological assessment is critical in order to determine the effects of nanomaterials in humans and other biological systems. Expanding the knowledge of nanoparticle toxicity will facilitate designing of safer nanocomposites and their application in a beneficial manner.
KW - Extracellular matrix
KW - Nanomedicine
KW - Nanoparticles
KW - Nanotechnology
KW - Nanotoxicology
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U2 - 10.1016/j.fct.2016.03.003
DO - 10.1016/j.fct.2016.03.003
M3 - Review article
C2 - 26969113
AN - SCOPUS:84960427574
SN - 0278-6915
VL - 91
SP - 42
EP - 57
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
ER -