Emerging aspects of nanotoxicology in health and disease: From agriculture and food sector to cancer therapeutics

Zoi Piperigkou, Konstantina Karamanou, Ayse Basak Engin, Chrysostomi Gialeli, Anca Oana Docea, Demitrios H. Vynios, Mauro S G Pavão, Kirill S. Golokhvast, Mikhail I. Shtilman, Athanassios Argiris, Ekaterina Shishatskaya, Aristidis M. Tsatsakis

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Nanotechnology is an evolving scientific field that has allowed the manufacturing of materials with novel physicochemical and biological properties, offering a wide spectrum of potential applications. Properties of nanoparticles that contribute to their usefulness include their markedly increased surface area in relation to mass, surface reactivity and insolubility, ability to agglomerate or change size in different media and enhanced endurance over conventional-scale substance. Here, we review nanoparticle classification and their emerging applications in several fields; from active food packaging to drug delivery and cancer research. Nanotechnology has exciting therapeutic applications, including novel drug delivery for the treatment of cancer. Additionally, we discuss that exposure to nanostructures incorporated to polymer composites, may result in potential human health risks. Therefore, the knowledge of processes, including absorption, distribution, metabolism and excretion, as well as careful toxicological assessment is critical in order to determine the effects of nanomaterials in humans and other biological systems. Expanding the knowledge of nanoparticle toxicity will facilitate designing of safer nanocomposites and their application in a beneficial manner.

Original languageEnglish (US)
Pages (from-to)42-57
Number of pages16
JournalFood and Chemical Toxicology
Volume91
DOIs
StatePublished - May 1 2016

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nanoparticles
Agriculture
Nanoparticles
nanomaterials
nanotechnology
Nanotechnology
Nanostructures
Health
agriculture
Food
therapeutics
neoplasms
Drug delivery
Food Packaging
nanocomposites
Nanocomposites
drugs
Neoplasms
composite polymers
food packaging

Keywords

  • Extracellular matrix
  • Nanomedicine
  • Nanoparticles
  • Nanotechnology
  • Nanotoxicology

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Piperigkou, Z., Karamanou, K., Engin, A. B., Gialeli, C., Docea, A. O., Vynios, D. H., ... Tsatsakis, A. M. (2016). Emerging aspects of nanotoxicology in health and disease: From agriculture and food sector to cancer therapeutics. Food and Chemical Toxicology, 91, 42-57. https://doi.org/10.1016/j.fct.2016.03.003

Emerging aspects of nanotoxicology in health and disease : From agriculture and food sector to cancer therapeutics. / Piperigkou, Zoi; Karamanou, Konstantina; Engin, Ayse Basak; Gialeli, Chrysostomi; Docea, Anca Oana; Vynios, Demitrios H.; Pavão, Mauro S G; Golokhvast, Kirill S.; Shtilman, Mikhail I.; Argiris, Athanassios; Shishatskaya, Ekaterina; Tsatsakis, Aristidis M.

In: Food and Chemical Toxicology, Vol. 91, 01.05.2016, p. 42-57.

Research output: Contribution to journalArticle

Piperigkou, Z, Karamanou, K, Engin, AB, Gialeli, C, Docea, AO, Vynios, DH, Pavão, MSG, Golokhvast, KS, Shtilman, MI, Argiris, A, Shishatskaya, E & Tsatsakis, AM 2016, 'Emerging aspects of nanotoxicology in health and disease: From agriculture and food sector to cancer therapeutics', Food and Chemical Toxicology, vol. 91, pp. 42-57. https://doi.org/10.1016/j.fct.2016.03.003
Piperigkou, Zoi ; Karamanou, Konstantina ; Engin, Ayse Basak ; Gialeli, Chrysostomi ; Docea, Anca Oana ; Vynios, Demitrios H. ; Pavão, Mauro S G ; Golokhvast, Kirill S. ; Shtilman, Mikhail I. ; Argiris, Athanassios ; Shishatskaya, Ekaterina ; Tsatsakis, Aristidis M. / Emerging aspects of nanotoxicology in health and disease : From agriculture and food sector to cancer therapeutics. In: Food and Chemical Toxicology. 2016 ; Vol. 91. pp. 42-57.
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