Abstract
Inherited mutations in the human BRCA2 gene cause about half of the cauca of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2- deficient embryos, their radiation sensitivity, and the asssociation of Brca2 with Rud51 indicate that Brca2 may be an essential cofactor in the Rud51- dependent DNA repair of double-strand breaks, thereby explaining the tumour- suppressor function of Brca2.
Original language | English (US) |
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Pages (from-to) | 804-810 |
Number of pages | 7 |
Journal | Nature |
Volume | 386 |
Issue number | 6627 |
DOIs | |
State | Published - Apr 24 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- General