Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Shyam K. Sharan; Masami Morimatsu; Urs Albrecht; Dae Sik Lim; Eva Regel; Christopher Dinh; Arthur Sands; Gregor Eichele; Paul Hasty; Allan Bradley

doi:10.1038/386804a0

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Shyam K. Sharan, Masami Morimatsu, Urs Albrecht, Dae Sik Lim, Eva Regel, Christopher Dinh, Arthur Sands, Gregor Eichele, Paul Hasty, Allan Bradley

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Abstract

Inherited mutations in the human BRCA2 gene cause about half of the cauca of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2- deficient embryos, their radiation sensitivity, and the asssociation of Brca2 with Rud51 indicate that Brca2 may be an essential cofactor in the Rud51- dependent DNA repair of double-strand breaks, thereby explaining the tumour- suppressor function of Brca2.

Original language	English (US)
Pages (from-to)	804-810
Number of pages	7
Journal	Nature
Volume	386
Issue number	6627
DOIs	https://doi.org/10.1038/386804a0
State	Published - Apr 24 1997
Externally published	Yes

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title = "Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2",

abstract = "Inherited mutations in the human BRCA2 gene cause about half of the cauca of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2- deficient embryos, their radiation sensitivity, and the asssociation of Brca2 with Rud51 indicate that Brca2 may be an essential cofactor in the Rud51- dependent DNA repair of double-strand breaks, thereby explaining the tumour- suppressor function of Brca2.",

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T1 - Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

AU - Sharan, Shyam K.

AU - Morimatsu, Masami

AU - Albrecht, Urs

AU - Lim, Dae Sik

AU - Regel, Eva

AU - Dinh, Christopher

AU - Sands, Arthur

AU - Eichele, Gregor

AU - Hasty, Paul

AU - Bradley, Allan

PY - 1997/4/24

Y1 - 1997/4/24

N2 - Inherited mutations in the human BRCA2 gene cause about half of the cauca of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2- deficient embryos, their radiation sensitivity, and the asssociation of Brca2 with Rud51 indicate that Brca2 may be an essential cofactor in the Rud51- dependent DNA repair of double-strand breaks, thereby explaining the tumour- suppressor function of Brca2.

AB - Inherited mutations in the human BRCA2 gene cause about half of the cauca of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2- deficient embryos, their radiation sensitivity, and the asssociation of Brca2 with Rud51 indicate that Brca2 may be an essential cofactor in the Rud51- dependent DNA repair of double-strand breaks, thereby explaining the tumour- suppressor function of Brca2.

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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