Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Shyam K. Sharan, Masami Morimatsu, Urs Albrecht, Dae Sik Lim, Eva Regel, Christopher Dinh, Arthur Sands, Gregor Eichele, Paul Hasty, Allan Bradley

Research output: Contribution to journalArticlepeer-review

856 Scopus citations

Abstract

Inherited mutations in the human BRCA2 gene cause about half of the cauca of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2- deficient embryos, their radiation sensitivity, and the asssociation of Brca2 with Rud51 indicate that Brca2 may be an essential cofactor in the Rud51- dependent DNA repair of double-strand breaks, thereby explaining the tumour- suppressor function of Brca2.

Original languageEnglish (US)
Pages (from-to)804-810
Number of pages7
JournalNature
Volume386
Issue number6627
DOIs
StatePublished - Apr 24 1997

ASJC Scopus subject areas

  • General

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