Elevations in growth hormone and glucagon-like peptide-2 levels on admission are associated with increased mortality in trauma patients

Matthew P. Rowan, Darrick J. Beckman, Julie A. Rizzo, Claire L. Isbell, Christopher E. White, Stephen M. Cohn, Kevin K. Chung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Burn and trauma patients present a clinical challenge due to metabolic derangements and hypermetabolism that result in a prolonged catabolic state with impaired healing and secondary complications, including ventilator dependence. Previous work has shown that circulating levels of growth hormone (GH) are predictive of mortality in critically ill adults, but few studies have examined the prognostic potential of GH levels in adult trauma patients. Methods: To investigate the utility of GH and other endocrine responses in the prediction of outcomes, we conducted a prospective, observational study of adult burn and trauma patients. We evaluated the serum concentration of GH, insulin-like growth factor 1 (IGF-1), IGF binding protein 3 (IGFBP-3), and glucagon-like peptide-2 (GLP-2) weekly for up to 6 weeks in 36 adult burn and trauma patients admitted between 2010 and 2013. Results: Non-survivors had significantly higher levels of GH and GLP-2 on admission than survivors. Discussion: This study demonstrates that GH has potential as a predictor of mortality in critically ill trauma and burn patients. Future studies will focus on not only the role of GH, but also GLP-2, which was shown to correlate with mortality in this study with a goal of offering early, targeted therapeutic interventions aimed at decreasing mortality in the critically injured. Conclusions: GH and GLP-2 may have clinical utility for outcome prediction in adult trauma patients.

Original languageEnglish (US)
Article number119
JournalScandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Volume24
Issue number1
DOIs
StatePublished - Oct 4 2016
Externally publishedYes

Fingerprint

Glucagon-Like Peptide 2
Growth Hormone
Mortality
Wounds and Injuries
Critical Illness
Insulin-Like Growth Factor Binding Protein 3
Somatomedins
Mechanical Ventilators
Observational Studies
Survivors
Prospective Studies

Keywords

  • Biomarker
  • Burn
  • Hormone
  • Hypermetabolism
  • Trauma

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Elevations in growth hormone and glucagon-like peptide-2 levels on admission are associated with increased mortality in trauma patients. / Rowan, Matthew P.; Beckman, Darrick J.; Rizzo, Julie A.; Isbell, Claire L.; White, Christopher E.; Cohn, Stephen M.; Chung, Kevin K.

In: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Vol. 24, No. 1, 119, 04.10.2016.

Research output: Contribution to journalArticle

Rowan, Matthew P. ; Beckman, Darrick J. ; Rizzo, Julie A. ; Isbell, Claire L. ; White, Christopher E. ; Cohn, Stephen M. ; Chung, Kevin K. / Elevations in growth hormone and glucagon-like peptide-2 levels on admission are associated with increased mortality in trauma patients. In: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2016 ; Vol. 24, No. 1.
@article{1ad9c20e6d26410e910efab81769354a,
title = "Elevations in growth hormone and glucagon-like peptide-2 levels on admission are associated with increased mortality in trauma patients",
abstract = "Background: Burn and trauma patients present a clinical challenge due to metabolic derangements and hypermetabolism that result in a prolonged catabolic state with impaired healing and secondary complications, including ventilator dependence. Previous work has shown that circulating levels of growth hormone (GH) are predictive of mortality in critically ill adults, but few studies have examined the prognostic potential of GH levels in adult trauma patients. Methods: To investigate the utility of GH and other endocrine responses in the prediction of outcomes, we conducted a prospective, observational study of adult burn and trauma patients. We evaluated the serum concentration of GH, insulin-like growth factor 1 (IGF-1), IGF binding protein 3 (IGFBP-3), and glucagon-like peptide-2 (GLP-2) weekly for up to 6 weeks in 36 adult burn and trauma patients admitted between 2010 and 2013. Results: Non-survivors had significantly higher levels of GH and GLP-2 on admission than survivors. Discussion: This study demonstrates that GH has potential as a predictor of mortality in critically ill trauma and burn patients. Future studies will focus on not only the role of GH, but also GLP-2, which was shown to correlate with mortality in this study with a goal of offering early, targeted therapeutic interventions aimed at decreasing mortality in the critically injured. Conclusions: GH and GLP-2 may have clinical utility for outcome prediction in adult trauma patients.",
keywords = "Biomarker, Burn, Hormone, Hypermetabolism, Trauma",
author = "Rowan, {Matthew P.} and Beckman, {Darrick J.} and Rizzo, {Julie A.} and Isbell, {Claire L.} and White, {Christopher E.} and Cohn, {Stephen M.} and Chung, {Kevin K.}",
year = "2016",
month = "10",
day = "4",
doi = "10.1186/s13049-016-0310-8",
language = "English (US)",
volume = "24",
journal = "Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine",
issn = "1757-7241",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Elevations in growth hormone and glucagon-like peptide-2 levels on admission are associated with increased mortality in trauma patients

AU - Rowan, Matthew P.

AU - Beckman, Darrick J.

AU - Rizzo, Julie A.

AU - Isbell, Claire L.

AU - White, Christopher E.

AU - Cohn, Stephen M.

AU - Chung, Kevin K.

PY - 2016/10/4

Y1 - 2016/10/4

N2 - Background: Burn and trauma patients present a clinical challenge due to metabolic derangements and hypermetabolism that result in a prolonged catabolic state with impaired healing and secondary complications, including ventilator dependence. Previous work has shown that circulating levels of growth hormone (GH) are predictive of mortality in critically ill adults, but few studies have examined the prognostic potential of GH levels in adult trauma patients. Methods: To investigate the utility of GH and other endocrine responses in the prediction of outcomes, we conducted a prospective, observational study of adult burn and trauma patients. We evaluated the serum concentration of GH, insulin-like growth factor 1 (IGF-1), IGF binding protein 3 (IGFBP-3), and glucagon-like peptide-2 (GLP-2) weekly for up to 6 weeks in 36 adult burn and trauma patients admitted between 2010 and 2013. Results: Non-survivors had significantly higher levels of GH and GLP-2 on admission than survivors. Discussion: This study demonstrates that GH has potential as a predictor of mortality in critically ill trauma and burn patients. Future studies will focus on not only the role of GH, but also GLP-2, which was shown to correlate with mortality in this study with a goal of offering early, targeted therapeutic interventions aimed at decreasing mortality in the critically injured. Conclusions: GH and GLP-2 may have clinical utility for outcome prediction in adult trauma patients.

AB - Background: Burn and trauma patients present a clinical challenge due to metabolic derangements and hypermetabolism that result in a prolonged catabolic state with impaired healing and secondary complications, including ventilator dependence. Previous work has shown that circulating levels of growth hormone (GH) are predictive of mortality in critically ill adults, but few studies have examined the prognostic potential of GH levels in adult trauma patients. Methods: To investigate the utility of GH and other endocrine responses in the prediction of outcomes, we conducted a prospective, observational study of adult burn and trauma patients. We evaluated the serum concentration of GH, insulin-like growth factor 1 (IGF-1), IGF binding protein 3 (IGFBP-3), and glucagon-like peptide-2 (GLP-2) weekly for up to 6 weeks in 36 adult burn and trauma patients admitted between 2010 and 2013. Results: Non-survivors had significantly higher levels of GH and GLP-2 on admission than survivors. Discussion: This study demonstrates that GH has potential as a predictor of mortality in critically ill trauma and burn patients. Future studies will focus on not only the role of GH, but also GLP-2, which was shown to correlate with mortality in this study with a goal of offering early, targeted therapeutic interventions aimed at decreasing mortality in the critically injured. Conclusions: GH and GLP-2 may have clinical utility for outcome prediction in adult trauma patients.

KW - Biomarker

KW - Burn

KW - Hormone

KW - Hypermetabolism

KW - Trauma

UR - http://www.scopus.com/inward/record.url?scp=84990070044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84990070044&partnerID=8YFLogxK

U2 - 10.1186/s13049-016-0310-8

DO - 10.1186/s13049-016-0310-8

M3 - Article

C2 - 27716276

AN - SCOPUS:84990070044

VL - 24

JO - Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

JF - Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

SN - 1757-7241

IS - 1

M1 - 119

ER -