Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide

Juan M. Guerrero, Russel J. Reiter, Burkhard Poeggeler, Li‐Dun ‐D Chen, Dun‐Xian ‐X Tan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Guerrero JM, Reiter RJ, Poeggeler B, Chen L‐D, Tan D‐X. Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide. J Pineal Res. 1994:16:210–214. The present paper reports that nitric oxide (NO) released by sodium nitroprusside (SNP) is a potent activator of rat pineal cyclic GMP production without affecting cyclic AMP synthesis. Other drugs such as isoproterenol, vasoactive intestinal peptide, and peptide histidine isoleucine were ineffective in stimulating cyclic GMP production, but activated cyclic AMP production. However, L‐arginine, the physiological precursor of NO, did not activate either cyclic GMP or NO synthesis. Because L‐arginine failed to activate cyclic GMP production, results suggest that NO is not produced in the pineal gland, but behaves as a potent regulator of this cyclic nucleotide.

Original languageEnglish (US)
Pages (from-to)210-214
Number of pages5
JournalJournal of pineal research
Volume16
Issue number4
DOIs
StatePublished - May 1994

Keywords

  • nitric oxide
  • pineal gland‐cyclic GMP

ASJC Scopus subject areas

  • Endocrinology

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