TY - JOUR
T1 - Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide
AU - Guerrero, Juan M.
AU - Reiter, Russel J.
AU - Poeggeler, Burkhard
AU - Chen, Li‐Dun ‐D
AU - Tan, Dun‐Xian ‐X
PY - 1994/5
Y1 - 1994/5
N2 - Guerrero JM, Reiter RJ, Poeggeler B, Chen L‐D, Tan D‐X. Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide. J Pineal Res. 1994:16:210–214. The present paper reports that nitric oxide (NO) released by sodium nitroprusside (SNP) is a potent activator of rat pineal cyclic GMP production without affecting cyclic AMP synthesis. Other drugs such as isoproterenol, vasoactive intestinal peptide, and peptide histidine isoleucine were ineffective in stimulating cyclic GMP production, but activated cyclic AMP production. However, L‐arginine, the physiological precursor of NO, did not activate either cyclic GMP or NO synthesis. Because L‐arginine failed to activate cyclic GMP production, results suggest that NO is not produced in the pineal gland, but behaves as a potent regulator of this cyclic nucleotide.
AB - Guerrero JM, Reiter RJ, Poeggeler B, Chen L‐D, Tan D‐X. Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide. J Pineal Res. 1994:16:210–214. The present paper reports that nitric oxide (NO) released by sodium nitroprusside (SNP) is a potent activator of rat pineal cyclic GMP production without affecting cyclic AMP synthesis. Other drugs such as isoproterenol, vasoactive intestinal peptide, and peptide histidine isoleucine were ineffective in stimulating cyclic GMP production, but activated cyclic AMP production. However, L‐arginine, the physiological precursor of NO, did not activate either cyclic GMP or NO synthesis. Because L‐arginine failed to activate cyclic GMP production, results suggest that NO is not produced in the pineal gland, but behaves as a potent regulator of this cyclic nucleotide.
KW - nitric oxide
KW - pineal gland‐cyclic GMP
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U2 - 10.1111/j.1600-079X.1994.tb00104.x
DO - 10.1111/j.1600-079X.1994.tb00104.x
M3 - Article
C2 - 7807377
AN - SCOPUS:0028440938
VL - 16
SP - 210
EP - 214
JO - Journal of Pineal Research
JF - Journal of Pineal Research
SN - 0742-3098
IS - 4
ER -