Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide

Juan M. Guerrero; Russel J. Reiter; Burkhard Poeggeler; Li‐Dun ‐D Chen; Dun‐Xian ‐X Tan

doi:10.1111/j.1600-079X.1994.tb00104.x

Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide

Juan M. Guerrero, Russel J. Reiter, Burkhard Poeggeler, Li‐Dun ‐D Chen, Dun‐Xian ‐X Tan

Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Guerrero JM, Reiter RJ, Poeggeler B, Chen L‐D, Tan D‐X. Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide. J Pineal Res. 1994:16:210–214. The present paper reports that nitric oxide (NO) released by sodium nitroprusside (SNP) is a potent activator of rat pineal cyclic GMP production without affecting cyclic AMP synthesis. Other drugs such as isoproterenol, vasoactive intestinal peptide, and peptide histidine isoleucine were ineffective in stimulating cyclic GMP production, but activated cyclic AMP production. However, L‐arginine, the physiological precursor of NO, did not activate either cyclic GMP or NO synthesis. Because L‐arginine failed to activate cyclic GMP production, results suggest that NO is not produced in the pineal gland, but behaves as a potent regulator of this cyclic nucleotide.

Original language	English (US)
Pages (from-to)	210-214
Number of pages	5
Journal	Journal of pineal research
Volume	16
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-079X.1994.tb00104.x
State	Published - May 1994

Keywords

nitric oxide
pineal gland‐cyclic GMP

ASJC Scopus subject areas

Endocrinology

Access to Document

10.1111/j.1600-079X.1994.tb00104.x

Fingerprint Dive into the research topics of 'Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide'. Together they form a unique fingerprint.

Cite this

@article{c5eff14648f0438dacacc29256535dae,

title = "Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide",

abstract = "Guerrero JM, Reiter RJ, Poeggeler B, Chen L‐D, Tan D‐X. Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide. J Pineal Res. 1994:16:210–214. The present paper reports that nitric oxide (NO) released by sodium nitroprusside (SNP) is a potent activator of rat pineal cyclic GMP production without affecting cyclic AMP synthesis. Other drugs such as isoproterenol, vasoactive intestinal peptide, and peptide histidine isoleucine were ineffective in stimulating cyclic GMP production, but activated cyclic AMP production. However, L‐arginine, the physiological precursor of NO, did not activate either cyclic GMP or NO synthesis. Because L‐arginine failed to activate cyclic GMP production, results suggest that NO is not produced in the pineal gland, but behaves as a potent regulator of this cyclic nucleotide.",

keywords = "nitric oxide, pineal gland‐cyclic GMP",

author = "Guerrero, {Juan M.} and Reiter, {Russel J.} and Burkhard Poeggeler and Chen, {Li‐Dun ‐D} and Tan, {Dun‐Xian ‐X}",

year = "1994",

month = may,

doi = "10.1111/j.1600-079X.1994.tb00104.x",

language = "English (US)",

volume = "16",

pages = "210--214",

journal = "Journal of Pineal Research",

issn = "0742-3098",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide

AU - Guerrero, Juan M.

AU - Reiter, Russel J.

AU - Poeggeler, Burkhard

AU - Chen, Li‐Dun ‐D

AU - Tan, Dun‐Xian ‐X

PY - 1994/5

Y1 - 1994/5

N2 - Guerrero JM, Reiter RJ, Poeggeler B, Chen L‐D, Tan D‐X. Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide. J Pineal Res. 1994:16:210–214. The present paper reports that nitric oxide (NO) released by sodium nitroprusside (SNP) is a potent activator of rat pineal cyclic GMP production without affecting cyclic AMP synthesis. Other drugs such as isoproterenol, vasoactive intestinal peptide, and peptide histidine isoleucine were ineffective in stimulating cyclic GMP production, but activated cyclic AMP production. However, L‐arginine, the physiological precursor of NO, did not activate either cyclic GMP or NO synthesis. Because L‐arginine failed to activate cyclic GMP production, results suggest that NO is not produced in the pineal gland, but behaves as a potent regulator of this cyclic nucleotide.

AB - Guerrero JM, Reiter RJ, Poeggeler B, Chen L‐D, Tan D‐X. Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide. J Pineal Res. 1994:16:210–214. The present paper reports that nitric oxide (NO) released by sodium nitroprusside (SNP) is a potent activator of rat pineal cyclic GMP production without affecting cyclic AMP synthesis. Other drugs such as isoproterenol, vasoactive intestinal peptide, and peptide histidine isoleucine were ineffective in stimulating cyclic GMP production, but activated cyclic AMP production. However, L‐arginine, the physiological precursor of NO, did not activate either cyclic GMP or NO synthesis. Because L‐arginine failed to activate cyclic GMP production, results suggest that NO is not produced in the pineal gland, but behaves as a potent regulator of this cyclic nucleotide.

KW - nitric oxide

KW - pineal gland‐cyclic GMP

UR - http://www.scopus.com/inward/record.url?scp=0028440938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028440938&partnerID=8YFLogxK

U2 - 10.1111/j.1600-079X.1994.tb00104.x

DO - 10.1111/j.1600-079X.1994.tb00104.x

M3 - Article

C2 - 7807377

AN - SCOPUS:0028440938

VL - 16

SP - 210

EP - 214

JO - Journal of Pineal Research

JF - Journal of Pineal Research

SN - 0742-3098

IS - 4

ER -