Elevated White Blood Cell Levels and Thrombotic Events in Patients With Polycythemia Vera: A Real-World Analysis of Veterans Health Administration Data

Shreekant Parasuraman; Jingbo Yu; Dilan Paranagama; Sulena Shrestha; Li Wang; Onur Baser; Robyn Scherber

doi:10.1016/j.clml.2019.11.010

Elevated White Blood Cell Levels and Thrombotic Events in Patients With Polycythemia Vera: A Real-World Analysis of Veterans Health Administration Data

Shreekant Parasuraman
, Jingbo Yu
, Dilan Paranagama
, Sulena Shrestha
, Li Wang
, Onur Baser
, Robyn Scherber

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Patients with polycythemia vera (PV) have a substantial risk of thrombotic events (TEs). In the present retrospective analysis using Veterans Health Administration claims data, 25% of 1565 patients experienced a TE during follow-up. We observed a positive, significant association between white blood cell (WBC) counts ≥ 8.5 × 10⁹/L and TE occurrence (reference, WBC count < 7.0 × 10⁹/L), supporting continued inclusion of WBC count control in disease management.

Original language	English (US)
Pages (from-to)	63-69
Number of pages	7
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.clml.2019.11.010
State	Published - Feb 2020
Externally published	Yes

Keywords

Leukocytosis
Retrospective analysis
Thrombosis
White blood cell count

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.clml.2019.11.010

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title = "Elevated White Blood Cell Levels and Thrombotic Events in Patients With Polycythemia Vera: A Real-World Analysis of Veterans Health Administration Data",

abstract = "Patients with polycythemia vera (PV) have a substantial risk of thrombotic events (TEs). In the present retrospective analysis using Veterans Health Administration claims data, 25\% of 1565 patients experienced a TE during follow-up. We observed a positive, significant association between white blood cell (WBC) counts ≥ 8.5 × 109/L and TE occurrence (reference, WBC count < 7.0 × 109/L), supporting continued inclusion of WBC count control in disease management.",

keywords = "Leukocytosis, Retrospective analysis, Thrombosis, White blood cell count",

author = "Shreekant Parasuraman and Jingbo Yu and Dilan Paranagama and Sulena Shrestha and Li Wang and Onur Baser and Robyn Scherber",

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doi = "10.1016/j.clml.2019.11.010",

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T1 - Elevated White Blood Cell Levels and Thrombotic Events in Patients With Polycythemia Vera

T2 - A Real-World Analysis of Veterans Health Administration Data

AU - Parasuraman, Shreekant

AU - Yu, Jingbo

AU - Paranagama, Dilan

AU - Shrestha, Sulena

AU - Wang, Li

AU - Baser, Onur

AU - Scherber, Robyn

PY - 2020/2

Y1 - 2020/2

N2 - Patients with polycythemia vera (PV) have a substantial risk of thrombotic events (TEs). In the present retrospective analysis using Veterans Health Administration claims data, 25% of 1565 patients experienced a TE during follow-up. We observed a positive, significant association between white blood cell (WBC) counts ≥ 8.5 × 109/L and TE occurrence (reference, WBC count < 7.0 × 109/L), supporting continued inclusion of WBC count control in disease management.

AB - Patients with polycythemia vera (PV) have a substantial risk of thrombotic events (TEs). In the present retrospective analysis using Veterans Health Administration claims data, 25% of 1565 patients experienced a TE during follow-up. We observed a positive, significant association between white blood cell (WBC) counts ≥ 8.5 × 109/L and TE occurrence (reference, WBC count < 7.0 × 109/L), supporting continued inclusion of WBC count control in disease management.

KW - Leukocytosis

KW - Retrospective analysis

KW - Thrombosis

KW - White blood cell count

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UR - https://www.scopus.com/pages/publications/85076827331#tab=citedBy

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AN - SCOPUS:85076827331

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JO - Clinical Lymphoma, Myeloma and Leukemia

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IS - 2

ER -

Elevated White Blood Cell Levels and Thrombotic Events in Patients With Polycythemia Vera: A Real-World Analysis of Veterans Health Administration Data

Abstract

Keywords

ASJC Scopus subject areas

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