Abstract
Objective: To assess the effect of an elevated serum P level on the day of hCG administration in an IVF cycle on resulting embryos by evaluating their performance at subsequent frozen ET. Design: A retrospective study. Participants: Ninety-six consecutive patients undergoing frozen ET cycles were studied in a tertiary care center. Main Outcome Measures: Serum obtained on the day of hCG administration in an IVF cycle was assayed for E2 and P by RIA. The main outcome measured was the development of a clinical pregnancy in a subsequent frozen ET cycle. Results: Using a previously described breakpoint in serum P concentration of 0.9 ng/mL (2.86 nmol/L), 8 of 69 (11.6%) frozen ETs in which embryos from low P level IVF cycles were transferred and 7 of 27 (25.9%) frozen ETs of embryos from elevated P level IVF cycles were transferred resulted in the development of clinical pregnancies. Although this does not clearly demonstrate superiority of embryos obtained from elevated P cycles, employing a power calculation, the probability that the pregnancy rate in the elevated serum P group is at least equal to the observed rate in the low P group is 92.8%. Conclusion: These data suggest that an elevated serum P level on the day of hCG administration does not adversely affect the quality of oocytes or resulting embryos.
Original language | English (US) |
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Pages (from-to) | 508-513 |
Number of pages | 6 |
Journal | Fertility and sterility |
Volume | 61 |
Issue number | 3 |
DOIs | |
State | Published - 1994 |
Keywords
- In vitro fertilization
- embryo quality
- frozen embryo transfer
- progesterone
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Reproductive Medicine