Elevated environmental temperature alters the responses of the reproductive and thyroid axes of female Syrian hamsters to afternoon melatonin injections

Russel J Reiter, Li Kang Li, A. Gonzalez-Brito, M. G. Tannenbaum, M. K. Vaughan, G. M. Vaughan, M. A. Villanua

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Female Syrian hamsters were kept in a light (14:10 h light:dark cycle, lights on 0600 h)- and temperature (22 or 30°C)-controlled room; some groups were treated with an afternoon s.c. injection of melatonin (6.25, 12.5, or 25 μg/day) for 11 or 14 weeks. The melatonin-induced suppression of the reproductive system in hamsters maintained at 22°C (as measured by vaginal cycles, uterine weights, ovarian histology, and plasma and pituitary prolactin levels) was delayed if hamsters were kept at 30°C. The dose-related depression of thyroxine (T4) after melatonin injections for 14 weeks in 22°C was not seen at 30°C. Rather, the depression of plasma T4 and triiodothyronine (T3) seen at the end of 11 or 14 weeks of exposure to 30°C without melatonin injections (vs. control levels at 22°C) was offset by melatonin injections, raising T4 and T3 particularly at the lower doses. In contrast, there was no consistent effect of higher temperature alone on reproductive variables. The interactive effects of temperature and melatonin on the reproductive and thyroidal systems in female hamsters are apparently complex and probably provide a fine-tuning mechanism for the environmental control of endocrine physiology.

Original languageEnglish (US)
Pages (from-to)301-315
Number of pages15
JournalJournal of Pineal Research
Volume5
Issue number3
StatePublished - 1988

Fingerprint

Mesocricetus
Melatonin
Thyroid Gland
Injections
Temperature
Cricetinae
Light
Photoperiod
Triiodothyronine
Thyroxine
Prolactin
Histology
Weights and Measures

ASJC Scopus subject areas

  • Endocrinology

Cite this

Reiter, R. J., Kang Li, L., Gonzalez-Brito, A., Tannenbaum, M. G., Vaughan, M. K., Vaughan, G. M., & Villanua, M. A. (1988). Elevated environmental temperature alters the responses of the reproductive and thyroid axes of female Syrian hamsters to afternoon melatonin injections. Journal of Pineal Research, 5(3), 301-315.

Elevated environmental temperature alters the responses of the reproductive and thyroid axes of female Syrian hamsters to afternoon melatonin injections. / Reiter, Russel J; Kang Li, Li; Gonzalez-Brito, A.; Tannenbaum, M. G.; Vaughan, M. K.; Vaughan, G. M.; Villanua, M. A.

In: Journal of Pineal Research, Vol. 5, No. 3, 1988, p. 301-315.

Research output: Contribution to journalArticle

Reiter, RJ, Kang Li, L, Gonzalez-Brito, A, Tannenbaum, MG, Vaughan, MK, Vaughan, GM & Villanua, MA 1988, 'Elevated environmental temperature alters the responses of the reproductive and thyroid axes of female Syrian hamsters to afternoon melatonin injections', Journal of Pineal Research, vol. 5, no. 3, pp. 301-315.
Reiter, Russel J ; Kang Li, Li ; Gonzalez-Brito, A. ; Tannenbaum, M. G. ; Vaughan, M. K. ; Vaughan, G. M. ; Villanua, M. A. / Elevated environmental temperature alters the responses of the reproductive and thyroid axes of female Syrian hamsters to afternoon melatonin injections. In: Journal of Pineal Research. 1988 ; Vol. 5, No. 3. pp. 301-315.
@article{f320f9cd195c4515a511960cde6629a0,
title = "Elevated environmental temperature alters the responses of the reproductive and thyroid axes of female Syrian hamsters to afternoon melatonin injections",
abstract = "Female Syrian hamsters were kept in a light (14:10 h light:dark cycle, lights on 0600 h)- and temperature (22 or 30°C)-controlled room; some groups were treated with an afternoon s.c. injection of melatonin (6.25, 12.5, or 25 μg/day) for 11 or 14 weeks. The melatonin-induced suppression of the reproductive system in hamsters maintained at 22°C (as measured by vaginal cycles, uterine weights, ovarian histology, and plasma and pituitary prolactin levels) was delayed if hamsters were kept at 30°C. The dose-related depression of thyroxine (T4) after melatonin injections for 14 weeks in 22°C was not seen at 30°C. Rather, the depression of plasma T4 and triiodothyronine (T3) seen at the end of 11 or 14 weeks of exposure to 30°C without melatonin injections (vs. control levels at 22°C) was offset by melatonin injections, raising T4 and T3 particularly at the lower doses. In contrast, there was no consistent effect of higher temperature alone on reproductive variables. The interactive effects of temperature and melatonin on the reproductive and thyroidal systems in female hamsters are apparently complex and probably provide a fine-tuning mechanism for the environmental control of endocrine physiology.",
author = "Reiter, {Russel J} and {Kang Li}, Li and A. Gonzalez-Brito and Tannenbaum, {M. G.} and Vaughan, {M. K.} and Vaughan, {G. M.} and Villanua, {M. A.}",
year = "1988",
language = "English (US)",
volume = "5",
pages = "301--315",
journal = "Journal of Pineal Research",
issn = "0742-3098",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Elevated environmental temperature alters the responses of the reproductive and thyroid axes of female Syrian hamsters to afternoon melatonin injections

AU - Reiter, Russel J

AU - Kang Li, Li

AU - Gonzalez-Brito, A.

AU - Tannenbaum, M. G.

AU - Vaughan, M. K.

AU - Vaughan, G. M.

AU - Villanua, M. A.

PY - 1988

Y1 - 1988

N2 - Female Syrian hamsters were kept in a light (14:10 h light:dark cycle, lights on 0600 h)- and temperature (22 or 30°C)-controlled room; some groups were treated with an afternoon s.c. injection of melatonin (6.25, 12.5, or 25 μg/day) for 11 or 14 weeks. The melatonin-induced suppression of the reproductive system in hamsters maintained at 22°C (as measured by vaginal cycles, uterine weights, ovarian histology, and plasma and pituitary prolactin levels) was delayed if hamsters were kept at 30°C. The dose-related depression of thyroxine (T4) after melatonin injections for 14 weeks in 22°C was not seen at 30°C. Rather, the depression of plasma T4 and triiodothyronine (T3) seen at the end of 11 or 14 weeks of exposure to 30°C without melatonin injections (vs. control levels at 22°C) was offset by melatonin injections, raising T4 and T3 particularly at the lower doses. In contrast, there was no consistent effect of higher temperature alone on reproductive variables. The interactive effects of temperature and melatonin on the reproductive and thyroidal systems in female hamsters are apparently complex and probably provide a fine-tuning mechanism for the environmental control of endocrine physiology.

AB - Female Syrian hamsters were kept in a light (14:10 h light:dark cycle, lights on 0600 h)- and temperature (22 or 30°C)-controlled room; some groups were treated with an afternoon s.c. injection of melatonin (6.25, 12.5, or 25 μg/day) for 11 or 14 weeks. The melatonin-induced suppression of the reproductive system in hamsters maintained at 22°C (as measured by vaginal cycles, uterine weights, ovarian histology, and plasma and pituitary prolactin levels) was delayed if hamsters were kept at 30°C. The dose-related depression of thyroxine (T4) after melatonin injections for 14 weeks in 22°C was not seen at 30°C. Rather, the depression of plasma T4 and triiodothyronine (T3) seen at the end of 11 or 14 weeks of exposure to 30°C without melatonin injections (vs. control levels at 22°C) was offset by melatonin injections, raising T4 and T3 particularly at the lower doses. In contrast, there was no consistent effect of higher temperature alone on reproductive variables. The interactive effects of temperature and melatonin on the reproductive and thyroidal systems in female hamsters are apparently complex and probably provide a fine-tuning mechanism for the environmental control of endocrine physiology.

UR - http://www.scopus.com/inward/record.url?scp=0023918075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023918075&partnerID=8YFLogxK

M3 - Article

C2 - 3404400

AN - SCOPUS:0023918075

VL - 5

SP - 301

EP - 315

JO - Journal of Pineal Research

JF - Journal of Pineal Research

SN - 0742-3098

IS - 3

ER -