Elevated cerebrospinal fluid SNAP-25 in schizophrenia

Peter M. Thompson, Mary Kelley, Jeffrey Yao, Guochuan Tsai, Daniel P. Van Kammen

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Background: Research suggests an association between abnormal exocytosis and schizophrenia. We previously demonstrated increased synaptosomal associated protein, 25 kDa (SNAP-25), a member of the exocytotic mechanism, in the cerebrospinal fluid (CSF) of schizophrenia subjects. In this study, we explored SNAP-25 level and clinical variables in a new group of subjects. Methods: Twenty-five haloperidol-treated subjects with chronic schizophrenia and twenty-five healthy control subjects participated in the study. Subjects received haloperidol treatment for at least 3 months and then had a lumbar puncture (n = 19). Medication was replaced by placebo, and the lumbar puncture was repeated (n = 25) after 6 weeks or sooner if limited psychotic symptoms occurred. We measured the level of SNAP-25 in the CSF and symptoms with the Brief Psychiatric Rating Scale (BPRS). Results: In both haloperidol (p = .001) and placebo (p = .001) treatment conditions, SNAP-25 was elevated. There was no significant difference in SNAP-25 level between conditions. We identified significant positive correlations among SNAP-25 and the BPRS total score and psychosis and thinking disturbance subscales in subjects on haloperidol. Conclusions: These observations confirm our previous report of elevated CSF SNAP-25 and suggest that synaptic pathology may be linked with the pathophysiology of schizophrenia.

Original languageEnglish (US)
Pages (from-to)1132-1137
Number of pages6
JournalBiological Psychiatry
Issue number12
StatePublished - Jun 15 2003


  • Cerebrospinal fluid
  • Exocytosis
  • Postmortem
  • Psychosis
  • SNAP-25
  • Schizophrenia
  • Synapse

ASJC Scopus subject areas

  • Biological Psychiatry


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