Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome

I. Jon Russell, Malcolm D. Orr, Bruce Littman, Gilbert A. Vipraio, David Alboukrek, Joel E. Michalek, Yolanda Lopez, Fane Mackillip

Research output: Contribution to journalArticle

530 Scopus citations

Abstract

Objective. To measure, and seek clinical correlates with, levels of substance P (SP) in the cerebrospinal fluid (CSF) of fibromyalgia syndrome (FMS) patients. Methods. CSF from 32 FMS patients and 30 normal control subjects was tested for SP by radio‐immunoassay. Clinical measures included tender point examination and standardized questionnaires. Results. CSF SP levels were 3‐fold higher in FMS patients than in normal controls (P < 0.001), but they correlated only weakly with tenderness found on examination. Conclusion. SP is significantly elevated in FMS CSF, but other abnormalities must exist in FMS to more fully explain the symptoms.

Original languageEnglish (US)
Pages (from-to)1593-1601
Number of pages9
JournalArthritis & Rheumatism
Volume37
Issue number11
DOIs
StatePublished - Nov 1994
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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    Russell, I. J., Orr, M. D., Littman, B., Vipraio, G. A., Alboukrek, D., Michalek, J. E., Lopez, Y., & Mackillip, F. (1994). Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome. Arthritis & Rheumatism, 37(11), 1593-1601. https://doi.org/10.1002/art.1780371106