Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome

I. Jon Russell; Malcolm D. Orr; Bruce Littman; Gilbert A. Vipraio; David Alboukrek; Joel E. Michalek; Yolanda Lopez; Fane Mackillip

doi:10.1002/art.1780371106

Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome

I. Jon Russell, Malcolm D. Orr, Bruce Littman, Gilbert A. Vipraio, David Alboukrek, Joel E. Michalek, Yolanda Lopez, Fane Mackillip

Division of Rheumatology

Research output: Contribution to journal › Article › peer-review

593 Scopus citations

Abstract

Objective. To measure, and seek clinical correlates with, levels of substance P (SP) in the cerebrospinal fluid (CSF) of fibromyalgia syndrome (FMS) patients. Methods. CSF from 32 FMS patients and 30 normal control subjects was tested for SP by radio‐immunoassay. Clinical measures included tender point examination and standardized questionnaires. Results. CSF SP levels were 3‐fold higher in FMS patients than in normal controls (P < 0.001), but they correlated only weakly with tenderness found on examination. Conclusion. SP is significantly elevated in FMS CSF, but other abnormalities must exist in FMS to more fully explain the symptoms.

Original language	English (US)
Pages (from-to)	1593-1601
Number of pages	9
Journal	Arthritis & Rheumatism
Volume	37
Issue number	11
DOIs	https://doi.org/10.1002/art.1780371106
State	Published - Nov 1994

ASJC Scopus subject areas

Pharmacology (medical)
Immunology and Allergy
Rheumatology
Immunology

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title = "Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome",

abstract = "Objective. To measure, and seek clinical correlates with, levels of substance P (SP) in the cerebrospinal fluid (CSF) of fibromyalgia syndrome (FMS) patients. Methods. CSF from 32 FMS patients and 30 normal control subjects was tested for SP by radio‐immunoassay. Clinical measures included tender point examination and standardized questionnaires. Results. CSF SP levels were 3‐fold higher in FMS patients than in normal controls (P < 0.001), but they correlated only weakly with tenderness found on examination. Conclusion. SP is significantly elevated in FMS CSF, but other abnormalities must exist in FMS to more fully explain the symptoms.",

author = "Russell, {I. Jon} and Orr, {Malcolm D.} and Bruce Littman and Vipraio, {Gilbert A.} and David Alboukrek and Michalek, {Joel E.} and Yolanda Lopez and Fane Mackillip",

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T1 - Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome

AU - Russell, I. Jon

AU - Orr, Malcolm D.

AU - Littman, Bruce

AU - Vipraio, Gilbert A.

AU - Alboukrek, David

AU - Michalek, Joel E.

AU - Lopez, Yolanda

AU - Mackillip, Fane

PY - 1994/11

Y1 - 1994/11

N2 - Objective. To measure, and seek clinical correlates with, levels of substance P (SP) in the cerebrospinal fluid (CSF) of fibromyalgia syndrome (FMS) patients. Methods. CSF from 32 FMS patients and 30 normal control subjects was tested for SP by radio‐immunoassay. Clinical measures included tender point examination and standardized questionnaires. Results. CSF SP levels were 3‐fold higher in FMS patients than in normal controls (P < 0.001), but they correlated only weakly with tenderness found on examination. Conclusion. SP is significantly elevated in FMS CSF, but other abnormalities must exist in FMS to more fully explain the symptoms.

AB - Objective. To measure, and seek clinical correlates with, levels of substance P (SP) in the cerebrospinal fluid (CSF) of fibromyalgia syndrome (FMS) patients. Methods. CSF from 32 FMS patients and 30 normal control subjects was tested for SP by radio‐immunoassay. Clinical measures included tender point examination and standardized questionnaires. Results. CSF SP levels were 3‐fold higher in FMS patients than in normal controls (P < 0.001), but they correlated only weakly with tenderness found on examination. Conclusion. SP is significantly elevated in FMS CSF, but other abnormalities must exist in FMS to more fully explain the symptoms.

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Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome

Abstract

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