Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism

TY - JOUR

T1 - Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism

AU - Hou, Shurong

AU - Li, Zhenzhen

AU - Chen, Xiaoling

AU - Wang, Wenxin

AU - Duan, Ting

AU - Scampavia, Louis

AU - Yuan, Yaxia

AU - Spicer, Timothy P.

AU - Chen, Xiabin

AU - Xie, Tian

N1 - Funding Information: This work was supported by the grant from the National Natural Science Foundation of China (Grant No. 81903108 to S. H.), the Key Project of Zhejiang Ministry of Science and Technology (Grant No. 2021C03087 to T. X.), and the Key Project of Hangzhou Ministry of Science and Technology (Grant No. 20212013B03 to T. X.). We thank Pierre Baillargeon and Lina Deluca at Scripps for their help with compound management, and Shujuan Zhao at Hangzhou Normal University for proteomics analysis. Funding Information: This work was supported by the grant from the National Natural Science Foundation of China (Grant No. 81903108 to S. H.), the Key Project of Zhejiang Ministry of Science and Technology (Grant No. 2021C03087 to T. X.), and the Key Project of Hangzhou Ministry of Science and Technology (Grant No. 20212013B03 to T. X.). We thank Pierre Baillargeon and Lina Deluca at Scripps for their help with compound management, and Shujuan Zhao at Hangzhou Normal University for proteomics analysis.

PY - 2023/12

Y1 - 2023/12

UR - http://www.scopus.com/inward/record.url?scp=85148972524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85148972524&partnerID=8YFLogxK

U2 - 10.1038/s41392-023-01373-z

DO - 10.1038/s41392-023-01373-z

M3 - Letter

C2 - 36849489

AN - SCOPUS:85148972524

SN - 2095-9907

VL - 8

JO - Signal Transduction and Targeted Therapy

JF - Signal Transduction and Targeted Therapy

IS - 1

M1 - 87

ER -