Electrophysiologic findings in multifocal motor neuropathy

J. S. Katz, G. I. Wolfe, W. W. Bryan, C. E. Jackson, A. A. Amato, Richard J. Barohn

Research output: Contribution to journalArticle

137 Scopus citations

Abstract

We performed detailed electrophysiologic studies on 16 patients with clinically defined multifocal motor neuropathy and found a wide spectrum of demyelinating features. Only five patients (31%) had conduction block in one or more nerves. However, in 15 patients (94%) at least one nerve showed other features of demyelination. We also noted a significant degree of superimposed axonal degeneration in 15 patients. Eight patients (50%) had individual nerves with pure axonal injury, despite the presence of demyelinating features in other nerves. Antiganglioside antibodies were elevated in four of five patients with conduction block and five of 11 patients without conduction block. We conclude that multifocal motor neuropathy is characterized electrophysiologically by a wide spectrum of axonal and demyelinating features. Diagnostic criteria requiring conduction block may lead to underdiagnosis of this potentially treatable neuropathy.

Original languageEnglish (US)
Pages (from-to)700-707
Number of pages8
JournalNeurology
Volume48
Issue number3
DOIs
StatePublished - Mar 1997
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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    Katz, J. S., Wolfe, G. I., Bryan, W. W., Jackson, C. E., Amato, A. A., & Barohn, R. J. (1997). Electrophysiologic findings in multifocal motor neuropathy. Neurology, 48(3), 700-707. https://doi.org/10.1212/WNL.48.3.700