Electroencephalographic sleep measures in prepubertal depression

Ronald E. Dahl, Neal D. Ryan, Boris Birmaher, Mayadah Al-Shabbout, Douglas E. Williamson, Martin Neidig, Beverly Nelson, Joaquim Puig-Antich

    Research output: Contribution to journalArticlepeer-review

    62 Scopus citations


    Two nights of electroencephalographic (EEG) sleep recording were performed in a group of prepubertal subjects with major depressive disorder (MDD) (n = 36, mean age = 10.4, SD = 1.5) and age-matched normal control children (n = 18, mean age = 10.1, SD = 1.6). All subjects were medically healthy and free of medications at the time of the study. There were no significant group differences for any major sleep variable after the initial adaptation night in this study. One subgroup of MDD subjects (n = 8) showed reduced REM latency on both recording nights, decreased stage 4 sleep, and increased REM time; this subgroup had significantly higher severity scores for depression but did not otherwise appear to be clinically distinct from the rest of the MDD subjects. Overall, the results indicate that the EEG sleep changes associated with depression in adults occurred less frequently in prepubertal MDD subjects.

    Original languageEnglish (US)
    Pages (from-to)201-214
    Number of pages14
    JournalPsychiatry Research
    Issue number2
    StatePublished - Aug 1991


    • Depression
    • prepubertal
    • psychobiology
    • rapid eye movement latency
    • sleep

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry


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