TY - JOUR
T1 - Electroencephalographic patterns during sleep in children with chromosome 15q11.2-13.1 duplications (Dup15q)
AU - Arkilo, Dimitrios
AU - Devinsky, Orrin
AU - Mudigoudar, Basanagoud
AU - Boronat, Susana
AU - Jennesson, Melanie
AU - Sassower, Kenneth
AU - Vaou, Okeanis Eleni
AU - Lerner, Jason T.
AU - Jeste, Shafali Spurling
AU - Luchsinger, Kadi
AU - Thibert, Ronald
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Our objective was to define the EEG features during sleep of children with neurodevelopmental disorders due to copy number gains of 15q11-q13 (Dup15q). We retrospectively reviewed continuous EEG recordings of 42 children with Dup15q (mean age: eight years, 32 with idic15), and data collected included background activity, interictal epileptiform discharges, sleep organization, and ictal activity. Three patterns were recognized:. Pattern 1: Alpha-delta sleep was noted in 14 children (33%), not associated with any clinical changes.Pattern 2: Electrical status epilepticus in sleep was noted in 15 children (35%), all diagnosed with treatment-resistant epilepsy. Thirteen of the 15 children had clinical seizures.Pattern 3: Frequent bursts of high amplitude bifrontal predominant, paroxysmal fast activity (12-15 Hz) during non-REM sleep was noted in 15 children (35%). All 15 children had treatment-resistant epilepsy.This is the first report of electroencephalographic patterns during sleep of children with Dup15q reporting alpha-delta rhythms, CSWS, and high amplitude fast frequencies. Alpha-delta rhythms are described in children with dysautonomia and/or mood disorders and CSWS in children with developmental regression. The significance of these findings in cognitive function and epilepsy for the children in our cohort needs to be determined with follow-up studies.
AB - Our objective was to define the EEG features during sleep of children with neurodevelopmental disorders due to copy number gains of 15q11-q13 (Dup15q). We retrospectively reviewed continuous EEG recordings of 42 children with Dup15q (mean age: eight years, 32 with idic15), and data collected included background activity, interictal epileptiform discharges, sleep organization, and ictal activity. Three patterns were recognized:. Pattern 1: Alpha-delta sleep was noted in 14 children (33%), not associated with any clinical changes.Pattern 2: Electrical status epilepticus in sleep was noted in 15 children (35%), all diagnosed with treatment-resistant epilepsy. Thirteen of the 15 children had clinical seizures.Pattern 3: Frequent bursts of high amplitude bifrontal predominant, paroxysmal fast activity (12-15 Hz) during non-REM sleep was noted in 15 children (35%). All 15 children had treatment-resistant epilepsy.This is the first report of electroencephalographic patterns during sleep of children with Dup15q reporting alpha-delta rhythms, CSWS, and high amplitude fast frequencies. Alpha-delta rhythms are described in children with dysautonomia and/or mood disorders and CSWS in children with developmental regression. The significance of these findings in cognitive function and epilepsy for the children in our cohort needs to be determined with follow-up studies.
KW - Children
KW - Dup15q syndrome
KW - EEG patterns
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=84959325296&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959325296&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2016.02.010
DO - 10.1016/j.yebeh.2016.02.010
M3 - Article
C2 - 26949155
AN - SCOPUS:84959325296
SN - 1525-5050
VL - 57
SP - 133
EP - 136
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
ER -