Electrical stimulation enhances select cellular/molecular functions of osteoblasts

Peter Supronowicz, Dennis Metzger, Bernard Arulanandam, Klaus Ullmann, Pulicke Ajayan, Rena Bizios

Research output: Contribution to journalConference articlepeer-review

Abstract

The present work investigated select cellular/molecular functions of rat calvaria osteoblasts (the bone-forming cells) cultured on current-conducting polylactic acid/carbon nanotube (PLA/CNT) composites following exposure to electrical stimulation (10 μA at 10 Hz) for 6 hours daily for up to 21 consecutive days. Compared to controls (that is, osteoblasts cultured on PLA/CNT composite substrates under standard cell culture conditions, but no electrical stimulation), exposure of osteoblasts to electrical stimulation resulted in a 46% increase in cell proliferation, a 300% increase in the concentration of extracellular calcium, and upregulation of Collagen Type I mRNA expression.

Original languageEnglish (US)
Pages (from-to)S-81
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - 2000
Externally publishedYes
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

ASJC Scopus subject areas

  • Biomedical Engineering

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