Electrical impedance scanning as a new breast cancer risk stratification tool for young women

Alexander Stojadinovic, Aviram Nissan, Craig D. Shriver, Elizabeth A. Mittendorf, Mark D. Akin, Vivian Dickerson, Sarah Lenington, Lawrence D. Platt, Thomas Stavros, Steven R. Goldstein, Orah Moskovitz, Zahava Gallimidi, Scott I. Fields, Arieh Yeshaya, Tanir M. Allweis, Raymond Manassa, Itzhak Pappo, Ron X. Ginor, Ralph B. D'Agostino, David Gur

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Background: Electrical impedance scanning (EIS) measures changes in breast tissue associated with breast cancer (Br-Ca) development. The T-Scan(tm2000 (ED is designed to use EIS to identify women ages 30-39 with elevated risk of breast cancer (i.e., T-Scan+ women). Aim: To estimate the relative probability of breast cancer in a T-Scan+ woman compared to a randomly selected young woman. Methods: A prospective, two-cohort trial was conducted in pre-menopausal women. The Specificity (Sp)-Cohort evaluated T-Scan specificity in 1,751 asymptomatic women ages 30-39. The Sensitivity)Sn)-Cohort evaluated T-Scan sensitivity in 390 women ages 45-30 scheduled for biopsy. Specificity, sensitivity, and conservative estimate of disease prevalence were used to calculate relative probability. Results: In the Sp-Cohort, 93 of 1,751 women were T-Scan+ (Sp = 94.7%; 95% CI: 93.7-95.7%). In the Sn-Cohort, 23 of 87 biopsy-proven cancers were T-Scan+ (Sn = 26.4%; 95% CI: 17.4-35.4%). Given Sp = 94.7%, Sn = 26.4% and prevalence of 1.5 cancers/1,000 women (ages 30-39), the relative probability of a T-Scan+ woman having Br-Ca is 4.95: (95% CI: 3.16-7.14). Conclusion: EIS can identify a subset of young women with a relative probability of breast cancer almost five times greater than in the population of young women at-large. T-Scan+ women have a sufficiently high risk of Br-Ca to warrant further surveillance or imaging.

Original languageEnglish (US)
Pages (from-to)112-120
Number of pages9
JournalJournal of Surgical Oncology
Volume97
Issue number2
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Keywords

  • Breast cancer
  • Electrical impedance
  • Screening

ASJC Scopus subject areas

  • Surgery
  • Oncology

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